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Roberto Abadie will discuss his latest book, The Professional Guinea Pig: Big Pharma and the Risky World of Human Subjects, where he documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified 鈥減rofessional guinea pigs鈥� in Philadelphia, Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating.