BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250916T144735EDT-8112BmZEuz@132.216.98.100 DTSTAMP:20250916T184735Z DESCRIPTION:The Feindel Brain and Mind Seminar Series will advance the visi on of Dr. William Feindel (1918–2014)\, Former Director of the Neuro (1972 –1984)\, to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology\, co gnitive neuroscience\, and neuroimaging.\n\nSpeakers will include scientis ts from across The Neuro\, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual fo rum for scientists and trainees to continue to foster interdisciplinary ex changes on the mechanisms\, diagnosis and treatment of brain and cognitive disorders.\n\n\nRegister for In-Person\n\nHost: Alain Dagher\n\n\nVascula r Risk Factors\, Cortical Atrophy\, and Dementia: Genes\, Cells\, and Mole cules\n\nAbstract: Zdenka Pausova will present research investigating the role of vascular risk factors in the etiology of cortical atrophy\, Alzhei mer’s disease\, and related dementia. Her work combines genetics and in si lico transcriptomics with brain magnetic resonance imaging (MRI) in large- scale\, population-based cohorts. This clinical research is complemented b y studies in mice\, which employ parallel brain MRI\, serial two-photon to mography\, and single-cell transcriptomics to provide cellular- and proces s-level insights.\n\nZdenka Pausova\n\nProfessor\, Department of Pediatric s\, University of Montreal\n\n\n\nFor the past 25 years\, Zdenka Pausova’s laboratory has studied the causes and consequences of obesity throughout the lifespan\, with recent work focusing on obesity as a negative vascular risk factor for brain health. With a background in medicine\, endocrinolo gy\, and genetics\, she integrates knowledge from these fields with the la test technological advances. Her team combines multi-omics—genetics\, epig enetics\, transcriptomics\, and metabolomics—with detailed phenotyping\, i ncluding brain and body magnetic resonance imaging\, in large-scale\, popu lation-based cohorts. Parallel studies in mouse models complement this res earch\, enabling exploration of causality and insights into cellular and m olecular mechanisms.\n\nDr. Pausova has published over 230 papers in peer- reviewed journals and holds an H-index of 77. She co-directs the Saguenay Youth Study (SYS)\, a longitudinal study of 2\,000 adolescents and their p arents investigating cardiometabolic and brain health. She contributes her expertise and SYS data to numerous international collaborative consortia\ , including NeuroCHARGE and ENIGMA. Within these collaborations\, she has recently led two major projects: (i) metabolomic profiling of cerebral sma ll vessel disease in over 9\,000 participants (Circulation\, 2022\, PMID: 35050683)\, and (ii) genetic studies of the relationships between cerebral small vessel disease\, cortical atrophy\, and dementia in more than 50\,0 00 participants\, complemented by replication in 500\,000 individuals (Nat ure Communications\, 2024\, PMID: 39496600). She has also leveraged other large-scale datasets\, including the UK Biobank\, where her team demonstra ted that cortical tissue loss in type 2 diabetes begins early—during the p rediabetic stage—and may involve dysregulated excitatory neuron signalling (Diabetes Care\, 2023\, PMID: 37824790).\n DTSTART:20250929T170000Z DTEND:20250929T180000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:Feindel Brain and Mind Seminar Series: Vascular Risk Factors\, Cort ical Atrophy\, and Dementia: Genes\, Cells\, and Molecules URL:/research/channels/event/feindel-brain-and-mind-se minar-series-vascular-risk-factors-cortical-atrophy-and-dementia-genes-367 520 END:VEVENT END:VCALENDAR