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DESCRIPTION:The genomic basis of bats' extended longevity and tolerant immu
 nity: Why should society care?\n\nEmma Teeling\, University College Dublin
 \n	Tuesday October 19\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/8542805
 6343\n\nAbstract: Of all mammals\, bat possess the most unique and peculia
 r adaptations that render them as excellent models to investigate the mech
 anisms of extended longevity and potentially halted senescence. Indeed\, t
 hey are the longest-lived mammals relative to their body size\, with the o
 ldest bat caught being >41 years old\, living approx. 8 times longer than 
 expected. Bats defy the ‘rate-of-living’ theories that propose a positive 
 correlation between body size and longevity as they use twice the energy a
 s other species of considerable size\, but live far longer. The mechanisms
  that bats use to avoid the negative physiological effects of their height
 ened metabolism and deal with an increased production of deleterious React
 ive Oxygen Species (ROS) is not known\, however it is suggested that they 
 either prevent or repair ROS damage. Bats also appear to have resistance t
 o many viral diseases such as rabies\, SARS and Ebola and are the suspecte
 d reservoir species for a huge diversity of newly discovered viruses\, inc
 luding Sars-CoV-2 This suggests that their innate immunity is different to
  other mammals\, perhaps playing a role in their unexpected longevity. Her
 e the potential genomic basis for their rare immunity and exceptional long
 evity is explored across multiple bat genomes and divergent ageing and imm
 une related markers (e.g. microbiome\, telomeres\, mitochondria\, cellular
  dynamics\, cytokine response) studied in wild bat populations. These find
 ings provide a deeper understanding of the causal mechanisms of ageing and
  tolerant immunity\, potentially uncovering the key molecular pathways tha
 t could be utilised to benefit society.\n
DTSTART:20211019T160000Z
DTEND:20211019T170000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Emma Teeling
URL:/qls/channels/event/qls-seminar-series-emma-teelin
 g-334139
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