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DTSTAMP:20250812T061601Z
DESCRIPTION:Conservation of structural long-range modules in RNAs\n\nVladim
 ir Reinharz\, UQAM\n	Tuesday January 12\, 12-1pm\n	Zoom Link: https:/mcgill.
 zoom.us/j/91589192037\n\nAbstract: \n\nRNA molecules fulfill a large amoun
 t of fundamental tasks in every living organism.\n	To achieve this vast arr
 ay of functions\, from transmitting information to biological sensors\, th
 ey rely on complex three-dimensional structures.\n	A low level representati
 on that only considers canonical base pairs\, called the secondary structu
 re\, has mathematical properties making it suitable for study under a Bolt
 zmann ensemble framework.\n	Dynamic programming algorithms have shown to be
  particularly adept to understand the link between secondary structure and
  sequence in that framework.\n	Yet this is not enough to fully grasp fine n
 etworks of interactions\, critical to the function\, that are not captured
  by the secondary structure.\n	\n	The Leontis-Westhof annotations of non-can
 onical interactions classifies all interactions beyond those in the second
 ary structure.\n	This ontology allows to represent RNA molecules in much mo
 re details\, and can then be described as directed graph with labelled edg
 es.\n	The discovery of conserved sub-structures can be transposed to the pr
 oblem of maximal edge sub-isomorphismes.\n	While classically NP-hard\, we c
 an take advantage of structural properties to restrain the ensemble of adm
 issible graphs.\n	In this talk\, I will present the algorithms we developed
  for that case and interesting results that where obtained [1].\n	I will sh
 ow utilities we offer to the community to analyze known and new structures
 \, through our website carnaval.lri.fr.\n	In particular\, I will highlight 
 the hierarchical organization of sub-structures\, and how they are spread 
 over vastly different functions.\n	\n	I will then speculate briefly over the
  role of chemical-modifications and future work.\n	\n	[1] Mining for recurre
 nt long-range interactions in RNA structures reveals embedded hierarchies 
 in network families\; Reinharz\, Soule\, Westhof\, Waldispuhl and Denise\;
  NAR\, 2018\n
DTSTART:20210112T170000Z
DTEND:20210112T180000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Vladimir Reinharz
URL:/qls/channels/event/qls-seminar-series-vladimir-re
 inharz-327398
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