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DTSTAMP:20250812T002440Z
DESCRIPTION:The paradox of fragile but dense bones in Type 2 diabetes\n\nEv
 e Donnelly\, Cornell University\n	Tuesday November 19\, 12-1pm\n	Zoom Link: 
 https://mcgill.zoom.us/j/89914150820\n	In Person: 550 Sherbrooke\, Room 189
 \n	\n	Abstract: Epidemiologic evidence from the past decade has demonstrated
  that increased bone fracture risk is one of the myriad clinical complicat
 ions of type 2 diabetes mellitus (T2DM). Counterintuitively\, the increase
 d fracture risk in T2DM occurs despite greater bone mineral density\, and 
 persists after accounting for potential confounders like body mass index\,
  neuropathies\, and falls. Therefore\, T2DM may alter aspects of bone’s in
 trinsic resistance to fracture beyond bone mineral density\, such as mater
 ial properties or microarchitecture\, thereby increasing bone fragility in
 dependently of bone mass. Although the mechanisms that underlie bone fragi
 lity in T2DM are not yet well established\, a multiplicity of factors\, in
 cluding hyperglycemia\, altered bone remodeling\, and non-enzymatic collag
 en crosslinking in the bone matrix are implicated. In this work we elucida
 te the factors that influence fragility in T2D by characterizing the bioch
 emical\, material\, microarchitectural\, and mechanical properties of bone
  from clinical populations of men and women with and without T2D. The canc
 ellous bone from patients with T2DM had greater concentrations of the adva
 nced glycation endproduct pentosidine and sugars bound to the collagen mat
 rix\, had greater mineral content\, and trended toward a greater bone volu
 me fraction than the non-DM specimens. Across study populations\, bone tis
 sue from patients with T2D had greater concentrations of AGEs and mineral 
 content. Our data suggest that high concentrations of AGEs can increase fr
 agility by reducing the ability of bone to absorb energy prior to failure\
 , especially for the subset of T2DM patients with low bone volume fraction
 . Further\, our statistical models show that an increase in bone volume fr
 action offers a protective effect for T2DM patients\, even with the inferi
 or intrinsic quality of the T2DM bone\, whereas loss of bone volume fracti
 on substantially increases risk of bone fragility for T2DM patients. The p
 rimary clinical implications of these findings are that preservation of bo
 ne volume fraction is critical in patients with T2DM.\n	 \n\nBiography: Dr.
  Donnelly is an Associate Professor of Materials Science and Engineering a
 t Cornell University. Her primary research focus is on the contribution of
  the organic and inorganic bone tissue constituents to material properties
  and whole-bone fracture resistance\, particularly in pathologic tissues. 
 Her group’s translational studies bridge basic materials science and clini
 cal research in orthopedics\, with the goal of identifying disease-induced
  alterations in mineral and matrix properties that can be targeted with th
 erapeutics or monitored as diagnostics of response to treatment interventi
 on.\n\nDr. Donnelly received her BS and MS in Materials Science and Engine
 ering at Stanford University and in 2007 she received her PhD in Mechanica
 l Engineering at Cornell University. As a postdoctoral fellow at the Hospi
 tal for Special Surgery Dr. Donnelly received an NIH Ruth L Kirchstein Nat
 ional Research Service Award for her postdoctoral fellowship examining the
  material properties of bone from individuals with fragility fractures.\n
 \nThe focus of her work is characterization of the contribution of tissue 
 microstructure and composition to the material and structural behavior of 
 healthy and pathologic connective tissues. The long-term goals of the work
  are to integrate materials science with translational orthopedic research
  to develop a mechanistic understanding of pathologic fractures in bone to
  identify the factors that contribute to the integrity of healthy bone tis
 sue (“bone quality”) and improve prediction of structural failure and trea
 tments that may restore function to diseased bone tissue.\n
DTSTART:20241119T170000Z
DTEND:20241119T180000Z
SUMMARY:QLS Seminar Series - Eve Donnelly
URL:/qls/channels/event/qls-seminar-series-eve-donnell
 y-358608
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