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DTSTAMP:20251220T121547Z
DESCRIPTION:From single to collective cell migration: A geometric bulk-surf
 ace PDE modelling approach\n\nAnotida Madzwamuse\, University of British C
 olumbia\n	Tuesday January 27\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/
 87078928687\n	In Person: 550 Sherbrooke\, Room 189\n	\n	Abstract: In this tal
 k\, I will present a new formalism for modelling single and collective cel
 l migration based on geometric bulk-surface partial differential equations
 . The cell plasma membrane and the nuclear envelope are modelled as energe
 tic manifolds whose evolution law is based on a force balance equation of 
 each material point on the two closed smooth evolving hypersurfaces (also 
 known as manifolds). The evolution law encodes all forces acting at each m
 aterial point in the outward pointing normal direction\, and these forces 
 include (but are not limited to) cell polarisation\, retraction\, bending 
 energy\, surface tension\, pressure\, volume or surface area constraint or
  conservation\, mechanics\, intra- and extra-cellular\, and so forth. Cell
  polarisation is modelled through bulk-surface reaction-diffusion systems 
 on continuously deforming manifolds. The fully coupled models are solved e
 fficiently by use of the evolving bulk-surface finite element method. To a
 llow for long time simulations\, robust adaptive mesh refined and equi-dis
 tribution strategies are implemented. To demonstrate the modelling approac
 h\, its generality and applicability\, several numerical simulations inspi
 red by studies in cell biology will be presented and comparisons to experi
 ments will be illustrated. This approach allows to study how single cells 
 migrate through non-isotropic environment\, microchannels of variable widt
 h as well as in confinement.\n
DTSTART:20260127T170000Z
DTEND:20260127T180000Z
SUMMARY:QLS Seminar Series - Anotida Madzwamuse
URL:/qls/channels/event/qls-seminar-series-anotida-mad
 zwamuse-369906
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