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DESCRIPTION:Retrospective Learning in the Brain\n\nBy Dr. Vijay Mohan K Nam
 boodiri from the Weill Institute for Neurosciences at the University of Ca
 lifornia\, San Francisco.\n\nIn-person event hosted by the 9IÖĆ×÷ł§Ăâ·Ń's Depart
 ment of Psychology\, will be held in Room 522 McIntyre Medical Building. A
  wine and cheese reception will follow.\n\nRetrospective Learning in the B
 rain\n	A hallmark of intelligence is the ability to learn associations betw
 een causes and effects (e.g.\, environmental cues and associated rewards).
  The near consensus understanding of the last few decades is that animals 
 learn cause-effect associations from errors in the prediction of the effec
 t (e.g.\, a reward prediction error or RPE). This theory has been hugely i
 nfluential in neuroscience as decades of evidence suggested that mesolimbi
 c dopamine (DA)— known to be critical for associative learning—appears to 
 signal RPE. Though some evidence questioned whether DA signals RPE\, the R
 PE hypothesis remained the best explanation of learning because no other n
 ormative theory of learning explained experimental observations inconsiste
 nt with RPE while also capturing phenomena explained by RPE. My lab has re
 cently provided such an alternative. Specifically\, we proposed a new theo
 ry of associative learning (named ANCCR\, read “anchor”) which postulates 
 that animals learn associations by retrospectively identifying causes of m
 eaningful effects such as rewards and that mesolimbic dopamine conveys tha
 t a current event is meaningful. The core idea is simple: you can learn to
  predict the future by retrodicting the past\, and you retrodict the past 
 only after meaningful events. Here\, I will present the basic formulation 
 of this theory\, some experimental data focused on distinguishing predicti
 ons of ANCCR and RPE\, unpublished experimental results demonstrating that
  behavioral and dopaminergic learning rates from cue-reward experiences ar
 e quantitatively scaled by reward sparsity\, and end with discussions rega
 rding the implications of the theory for translational applications for so
 me neuropsychological disorders involving maladaptive associative memories
 .\n\n \n
DTSTART:20240405T193000Z
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SUMMARY:Bindra Lecture
URL:/psychiatry/channels/event/bindra-lecture-355942
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