BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20251219T060033EST-7355Up5TKU@132.216.98.100 DTSTAMP:20251219T110033Z DESCRIPTION:Insights into Tauopathy Based on the Prion Model\n\nBy Dr. Marc Diamond\,Director\, Center for Alzheimer’s and Neurodegenrative Diseases\ , Distinguished Chair in Basic Brain Injury and Repair\, Peter O’Donnell J r. Brain Institute\, UTSouthwestern Medical Center\, Dallas\, Texas\, USA. \n\nZoom Meeting Link\n\nMeeting ID: 868 0061 3539\n Passcode: 535831\n\nIn sights into Tauopathy Based on the Prion Model\n\nThe prion hypothesis pre dicts that transcellular propagation of protein assemblies underlies progr essive neurodegeneration. A central idea is that unique\, self-propagating assembly structures\, termed strains\, causes distinct tauopathies. Our w ork in the past decade has provided critical support to this idea. The cur rent state-of-the-art in the structural analysis of strains is cryo-electr on microscopy\, which reveals a variety of relatively immobile “cores” in the fibrils derived from various tauopathies. We have sought to extend the characterization of tau strains using a dynamic analysis based on cell mo dels of tauopathy. We have exploited defined mutagenesis\, especially alan ine scans\, to define amino acids critical for the formation of different tau assemblies. This reveals “fingerprints” that define strains based on t heir propagation from relatively tiny amounts of soluble brain material. S urprisingly\, these findings correlate well with structures predicted by c ryo-EM\, suggesting that cellular models of tauopathy\, in addition to bei ng useful to study tau propagation\, will also provide structural informat ion about pathogenic tau assemblies. This presentation will inform the aud ience about the cell biology that underlies tau prion propagation and the characterization of tau strains.\n DTSTART:20210929T140000Z DTEND:20210929T150000Z SUMMARY:International Dementia Conference Series - 9I Centre for Studie s in Aging URL:/psychiatry/channels/event/international-dementia- conference-series-mcgill-centre-studies-aging-333496 END:VEVENT END:VCALENDAR