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UID:20250811T034154EDT-76585Mp2El@132.216.98.100
DTSTAMP:20250811T074154Z
DESCRIPTION:T cells play a central role in both eliminating pathogens and c
 ancers\, but are also drivers of autoimmunity. During T cell development i
 n the thymus\, a variety of mechanisms operate collectively to regulate T 
 cell tolerance. For CD8+ T cells\, the most well-studied central tolerance
  mechanism is clonal deletion\, however\, other mechanisms such as functio
 nal inactivation have been described. Our studies have shown that while ro
 bust clonal deletion can purge the T cell repertoire of most of the highly
  self-reactive CD8+ T cells\, anergy induction in the remaining highly sel
 f-reactive cells is needed for self-tolerance. Furthermore\, signaling thr
 ough the co-inhibitory receptor PD-1 is needed for establishment and maint
 enance of tolerance. Collectively\, our data shed light on the contributio
 ns of different central tolerance mechanisms and highlight the importance 
 of thymic anergy in self-tolerance.\n\n \n\nThis seminar will take place i
 n person\, details in attached poster below\n\n \n
DTSTART:20230814T150000Z
DTEND:20230814T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology and Microbiology & Immunology Seminar: Dr. Troy Baldwin:
  Controlling the killers: Mechanisms of CD8 T cell tolerance
URL:/physiology/channels/event/physiology-and-microbio
 logy-immunology-seminar-dr-troy-baldwin-controlling-killers-mechanisms-cd8
 -t-349266
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