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UID:20250811T202949EDT-08691XSoR0@132.216.98.100
DTSTAMP:20250812T002949Z
DESCRIPTION:Keynote Lecture: 'Biological defibrillation'\n\nThe implantable
  cardioverter defibrillator (ICD) is the product of electronic engineering
  and contains metal\, software\, and wires to establish a system in which 
 both a detector (i.e. sensor of electrical activity) and effector (i.e. hi
 gh voltage electroshock generator) are incorporated. Nature also makes use
  of such detector–effector systems where they control different physiologi
 cal processes. Such systems are the product of cells\, genes\, and protein
 s and involve a regulated variable\, set point\, and signaling between det
 ector and effector. Given their highly conservative nature\, these biologi
 cal systems are considered to be effective means to rapidly respond to sud
 den changes that\, if sustained\, may cause harm. Blood flow and immune re
 gulation are examples of such systems. In contrast\, the heart appears to 
 be devoid of a robust biological detector–effector system for counteractin
 g sustained hazardous arrhythmias. The heart does however\, have many diff
 erent ion channels\, which generate various electrical currents by opening
  and closing. This so-called gating is mainly voltage-dependent\, meaning 
 that certain ion channels in the cardiomyocyte membrane only open and clos
 e upon sensing a certain voltage. An ion channel can therefore be consider
 ed as a functional detector–effector unit. This notion creates a rationale
  to engineer an ion channel protein and integrate it into the plasma membr
 anes of cardiomyocytes to serve the same function as an ICD device\, namel
 y rapid detection and termination of arrhythmias. Such fully biological de
 fibrillation would not only have the benefit of being devoid of any hardwa
 re\, but would also be pain-free given its mode of arrhythmia termination.
 \n\nIn person Seminar: details in attached poster below\n
DTSTART:20230519T073000Z
DTEND:20230519T083000Z
LOCATION:Palmer Howard Amphitheatre\, Room 522\, McIntyre Medical Building\
 , CA\, QC\, Montreal\, H3G 1Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology 28th Annual Graduate Research Day speaker: Dr. Daniël A.
  Pijnappels
URL:/physiology/channels/event/physiology-28th-annual-
 graduate-research-day-speaker-dr-daniel-pijnappels-348222
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