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DTSTAMP:20250809T231504Z
DESCRIPTION:Dysfunctional dopamine (DA) signalling has been associated with
  a broad spectrum of neurological and psychiatric conditions\, prompting i
 nvestigations into how midbrain DA neuron heterogeneity may underpin this 
 variety of behavioural symptoms. Emerging literature indeed points to func
 tional heterogeneity even within anatomically defined DA clusters. Recogni
 zing the need for a systematic classification scheme\, we and others have 
 used single-cell profiling to catalogue DA neurons based on their gene exp
 ression profiles. In addition\, we’ve developed an intersectional platform
  to genetically target DA neuron subpopulations\, thus enabling their inve
 stigation in vivo. Using this platform\, we’ve revealed the unexpected com
 plexity of ascending DAergic projections and are currently investigating t
 he implication of this heterogeneity in behaviour and disease.\n\n \n
DTSTART:20221118T160000Z
DTEND:20221118T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar 'Mapping molecular and functional diversity with
 in the midbrain dopaminergic system”
URL:/physiology/channels/event/physiology-seminar-mapp
 ing-molecular-and-functional-diversity-within-midbrain-dopaminergic-system
 -343508
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