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UID:20250811T190114EDT-2960J8UOPK@132.216.98.100
DTSTAMP:20250811T230114Z
DESCRIPTION:Research in the Feske lab is focused on calcium and ionic signa
 ling in immune cells and its role in immune responses. We identified ORAI1
  as the gene encoding the Ca2+ release-activated Ca2+ (CRAC) channel and s
 howed that it forms the pore of the channel. We identified the first CRAC 
 channel-deficient patients with mutations in ORAI1 and its activator STIM1
  and thereby defined a new disease entity (CRAC channelopathy). Using knoc
 kout mice for Orai1\, Orai2\, Orai3\, Stim1 and Stim2\, we could show that
  CRAC channels are essential for physiological T cell functions during imm
 unity to infection and antitumor immunity as well as pathological T cell f
 unctions in autoimmune diseases and inflammation. Current CRAC channel rel
 ated research areas include the study of genetic defects of CRAC channel f
 unction in patients with mutations in ORAI1 and STIM1 genes\, of mechanism
 s by which CRAC channels regulate adaptive and innate immunity to infectio
 n and T cell-mediated autoimmunity (including multiple sclerosis and colit
 is) and allergic airway inflammation. In recent years\, the Feske lab has 
 made substantial efforts to identify new ion channels and transporters (IC
 Ts) that regulate immune responses by T cells\, B cells and macrophages. O
 nly a small fraction of the several hundred known ICTs are known to play a
  role in immune cells and immunity. Using expression analyses of ICTs in d
 ozens of immune cell subsets and forward genetic screening approaches in p
 rimary immune cells\, the lab is identifying new ion channels regulating i
 mmune responses. Examples of ICTs we identified to play a role in immune c
 ells are LRRC8C\, which transports Cl- and the second messenger cGAMP in T
  cells\, several zinc transporters\, proton channels and other ICTs that a
 re at various stages of investigation.\n\nThis seminar will be given onlin
 e via Zoom. Details in attached poster.\n
DTSTART:20220218T160000Z
DTEND:20220218T170000Z
SUMMARY:Online seminar - Electric stories: Of Ion Channels and Transporters
  in Immunity
URL:/physiology/channels/event/online-seminar-electric
 -stories-ion-channels-and-transporters-immunity-336601
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