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UID:20251006T180224EDT-8518Hjve4D@132.216.98.100
DTSTAMP:20251006T220224Z
DESCRIPTION:The nucleus is the characteristic feature of eukaryotic cells a
 nd houses the genomic information of the cell. The Lammerding laboratory i
 s combining cell and molecular biology approaches with tissue engineering 
 and microfabrication techniques\, live-cell microscopy\, and in vivo model
 s to investigate the interplay between nuclear structure\, mechanics\, and
  function. In particular\, the research is addressing how physical forces 
 acting on the nucleus\, for example\, in contracting muscle cells or durin
 g migration of cells through tight interstitial spaces\, can challenge the
  integrity of the nucleus\, alter its structure\, and cause genomic and tr
 anscriptional changes. I will present recent findings that demonstrate the
  importance of nuclear mechanics during cell migration in confined environ
 ments in vitro and in vivo\, as well as the functional consequences of cel
 ls having to squeeze their large nuclei through tight interstitial spaces 
 and small pores in the extracellular matrix network. In addition\, I will 
 discuss recent findings that highlight the importance of the nuclear envel
 ope proteins lamins A/C in mediating nuclear stability and mechanotransduc
 tion in mechanically stressed cells and tissues\, including how lamin muta
 tions result in reduced nuclear stability\, increased nuclear damage in st
 riated muscle cells\, and DNA damage and activation of DNA damage response
  pathways\, which may explain the tissue-specific defects in diseases caus
 ed by lamin mutations. Insights gained from these studies could improve pr
 ognostic approaches and motivate novel therapeutic approaches for these di
 seases.\n\nThis seminar will be given online via Zoom. Details in attached
  poster.\n
DTSTART:20201002T150000Z
DTEND:20201002T160000Z
SUMMARY:Online Seminar: Squish and Squeeze – Nuclear Mechanics in Physiolog
 y and Disease
URL:/physiology/channels/event/online-seminar-squish-a
 nd-squeeze-nuclear-mechanics-physiology-and-disease-323472
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