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UID:20250917T181534EDT-5998umhU1V@132.216.98.100
DTSTAMP:20250917T221534Z
DESCRIPTION:\n	The neural basis of abnormal social behavior in autism spectr
 um disorders (ASD) remains incompletely understood. As social behavior inv
 olves complex interactions between multiple brain regions\, a comprehensiv
 e understanding of disease mechanisms is best approached via brain-wide an
 alyses. We used two complementary but independent brain-wide mapping appro
 aches\, mouse resting-state fMRI and c-Fos-iDISCO imaging\, to construct b
 rain-wide activity maps of the Cntnap2 knockout mouse model of ASD. We fou
 nd lower activity and disrupted functional coupling across social brain re
 gions of these mice. Oxytocin administration\, which rescues social defici
 ts in these mice\, strongly stimulated these areas and normalized function
 al connectivity. Notably\, DREADD-triggered release of endogenous oxytocin
  strongly stimulated reward areas including the nucleus accumbens\, where 
 oxytocin receptor activation also rescued lowered excitatory synaptic driv
 e. Our findings establish circuit- and systems-level mechanisms of social 
 deficits in Cntnap2 knockout mice\, and reveal site-specific actions of ox
 ytocin promoting the coordinated activity of social brain regions.\n	\n	This
  seminar will be held online via Zoom.\n
DTSTART:20200424T150000Z
DTEND:20200424T160000Z
LOCATION:via Zoom\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y
 6\, 3655 promenade Sir William Osler
SUMMARY:Online Seminar: Unraveling mechanisms of social deficits in the Cnt
 nap2-KO mouse model of ASD
URL:/physiology/channels/event/online-seminar-unraveli
 ng-mechanisms-social-deficits-cntnap2-ko-mouse-model-asd-321480
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