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UID:20250809T202442EDT-3169aOJb5V@132.216.98.100
DTSTAMP:20250810T002442Z
DESCRIPTION:Mutation or disruption of the SHANK3 (SH3 domain and ankyrin re
 peat) gene at the 22q13.3 locus represents a highly penetrant\, monogenic 
 risk-factor for Autism Spectrum Disorder (ASD) and is a leading cause of P
 helan–McDermid Syndrome (PMS). Recent advances in gene editing enabled the
  creation of genetically engineered non-human primate (NHP) models of brai
 n disorders. Such NHP models might better approximate some neural and beha
 vioral features of ASD than rodents and allow for gaining a better neurobi
 ological understanding of ASD as well as developing treatment strategies. 
 I will be presenting a collaborative effort during my postdoctoral trainin
 g on a study of macaque monkeys carrying germline-transmissible SHANK3 mut
 ation generated with CRISPR/Cas9-mediated gene editing. The founder mutant
 s exhibited sleep disturbances\, motor deficits\, and increased repetitive
  behaviors\, as well as social and learning impairments. Examining resting
 -state brain activity in founder monkeys with functional magnetic resonanc
 e imaging revealed altered local and global connectivity patterns indicati
 ve of circuit abnormalities. Our findings of altered brain connectivity an
 d compromised behavioral performance in SHANK3 mutant macaques parallel so
 me aspects of the gene-circuit-behavior dysfunction in human ASD and PMS.
 \n\nThe F.C. MacIntosh Lectureship supports special seminars in neuroscien
 ce in honour of Dr. F.C. MacIntosh.\n
DTSTART:20200306T160000Z
DTEND:20200306T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - Genetic Engineering and Neural-behavioral Phenotyping of 
 a Macaque Model of ASD
URL:/physiology/channels/event/seminar-genetic-enginee
 ring-and-neural-behavioral-phenotyping-macaque-model-asd-304039
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