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UID:20250801T162401EDT-1303cE6orb@132.216.98.100
DTSTAMP:20250801T202401Z
DESCRIPTION:Pulsatile release of gonadotropin-releasing hormone (GnRH) from
  hypothalamic GnRH neurons is essential for reproductive health. Using dif
 ferent GnRH ”cell-lines”\, previous studies have shown that these neurons 
 (i) exhibit two modes of burst firing in their membrane potential in the t
 ime scale of seconds\; (ii) they exhibit cytosolic calcium oscillations in
  the time scale of minutes\; (iii) a subset of them express the GnRH recep
 tor\, a G-protein coupled receptor (GPCR)\, that allows for autocrine regu
 lation\; (iv) they respond to GnRH stimulation in a dose-dependent manner\
 ; and (v) they respond to stimulation to kisspeptin through a GPCR called 
 GPR54. We recently developed a mathematical model of a single GnRH neuron 
 that integrates all these components\, occurring at different time scales\
 , to explore how they interact collectively and produce pulsatile release 
 in the time scale of hours. The model revealed that electrical activity\, 
 autocrine feedback and kisspeptin stimulation must act in synergy to produ
 ce such pulsatility. It also showed that kisspeptin acts as a global signa
 l while autocrine feedback acts as a local signal to drive GnRH release\, 
 with approximately 7-1 locking between them\, and that electrical activity
  controls baseline release as well as rare release events. Using pulse tri
 ggered average\, we showed that this electrical activity was significantly
  reduced during a GnRH pulse\, an unexpected outcome. In this talk\, we wi
 ll give an overview of these results and their implications. \n
DTSTART:20190920T150000Z
DTEND:20190920T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - Local and Global Regulation of GnRH Secretion: A Potentia
 l Neuroendocrine Mechanism for Pulsatile Release
URL:/physiology/channels/event/seminar-local-and-globa
 l-regulation-gnrh-secretion-potential-neuroendocrine-mechanism-pulsatile-2
 98686
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