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DESCRIPTION:Register here\n\nStream via Vimeo here\n\n\nJustin Hicks\n\nPhD
 \, Radiochemist and Scientist\, Lawson Health Research Institute and Assis
 tant Professor\, Western University\n\nAbstract: Molecular imaging with PE
 T and SPECT has unequivocally changed how we study and understand diseases
 . These nuclear medicine imaging techniques have been especially useful in
  neurology where external access is limited. From simple diatomic oxygen t
 o drug-like species such as fluorodeoxyglucose or antibodies conjugates\, 
 there is an enormous scope of molecules that can be radiolabeled with an e
 qually large array of radionuclides. These “hot” tools can then be employe
 d to study the human body along an equally complex continuum of health and
  disease. By matching up the physical decay with the biological half-life\
 , everything from the rate of oxygen metabolism to the tumor progression c
 an be studied. Given the need to discover\, radiolabel\, and safely produc
 e radiopharmaceuticals\, it can be said that radiochemistry forms a founda
 tion for PET and SPECT imaging.\n\nWhile it is often flashy to describe ne
 w biomarkers/targets or the next great radiotracer innovation\, often the 
 nitty gritty of manufacturing these short-lived drugs is forgotten or not 
 understood. This can cause frustration among end-user when clinical approv
 al of radiotracers is delayed or there are last minute failures. For this 
 seminar\, I will provide insight into the clinical productions of very sho
 rt-lived radiotracers such as [15O]oxygen and water to show how even the s
 implest molecules have complicated regulatory hurdles to overcome. Next\, 
 I'll review our experiences translating clinical radiotracers from other s
 ites including [18F]SynVesT-1 (synaptic density)\, [18F]FEPPA (microglial 
 activation)\, and [18F]FEOBV (cholinergic tone). Throughout the above tran
 slation\, there is always room for improved methods. Our efforts to prepar
 e [11C]butanol\, [13N]ammonia\, and [18F]tetrafluoroborate will be used as
  examples. Lastly\, recent results to prepare 99mTc alternatives to popula
 r PET probes for amyloid beta plaques will be described. These SPECT deriv
 atives can be prepared in low resource setting where PET infrastructure is
  lacking\, and could provide a cost savings for routine use where PET is a
 vailable.\n\nParticipants will learn how radiotracer discovery is undertak
 en\, what is required to prepare radiotracers for human administration\, a
 nd why this last minute\, one chance process is simultaneously exciting an
 d frustrating for all involved.\n\n\nThe Feindel Brain and Mind Seminar Se
 ries will advance the vision of Dr. William Feindel (1918–2014)\, Former D
 irector of the Neuro (1972–1984)\, to constantly bridge the clinical and r
 esearch realms. The talks will highlight the latest advances and discoveri
 es in neuropsychology\, cognitive neuroscience\, and neuroimaging.\n\nSpea
 kers will include scientists from across The Neuro\, as well as colleagues
  and collaborators locally and from around the world. The series is intend
 ed to provide a virtual forum for scientists and trainees to continue to f
 oster interdisciplinary exchanges on the mechanisms\, diagnosis and treatm
 ent of brain and cognitive disorders.\n\n \n
DTSTART:20231030T170000Z
DTEND:20231030T180000Z
LOCATION:De Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Feindel Brain and Mind Seminar Series: Radiochemistry for Brain PET
  and SPECT
URL:/neuro/channels/event/feindel-brain-and-mind-semin
 ar-series-radiochemistry-brain-pet-and-spect-351181
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