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UID:20251221T162939EST-1599Mo3WHB@132.216.98.100
DTSTAMP:20251221T212939Z
DESCRIPTION:Supported by the generosity of the Killam Trusts\, the MNI's Ki
 llam Seminar Series invites outstanding guest speakers whose research is o
 f interest to the scientific community at the MNI and 9IÖÆ×÷³§Ãâ·Ñ.\n
 \n\nThe lecture is POSTPONED. \n\n\nAmit Zeisel\, PhD\n\nAssistant Profess
 or\, Faculty of Biotechnology and Food Engineering\, Russell Berrie Nanote
 chnology Institute\, Israel\n\nHost: Jean-François Poulin\n\nAbstract: The
  amygdala is a brain region primarily associated with emotional response. 
 The use of genetic markers and single-cell transcriptomics can provide ins
 ights into the behavior-associated cell state changes. Here\, we present a
  detailed cell type taxonomy of the adult mouse amygdala during fear learn
 ing and memory consolidation. We perform single-cell RNA-seq on naïve and 
 fear conditioned mice and identify 130 neuronal cell types\, whose spatial
  distributions is orthogonally validated. A subset of all neuronal types a
 re transcriptionally responsive to fear learning and memory retrieval. The
  activated engram cells upregulate activity response genes\, and coordinat
 e expression of genes associated with neurite outgrowth\, synaptic signali
 ng\, plasticity\, and development. We identify known and previously undesc
 ribed candidate genes responsive to fear learning. Our molecular atlas may
  be used to generate hypotheses to unveil the neuron types and neural circ
 uits regulating the emotional component of learning and memory\n
DTSTART:20231017T200000Z
DTEND:20231017T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:[POSTPONED] Killam Seminar Series: Cell Types in the Mouse Amygdala
  and Their Transcriptional Response to Fear Conditioning
URL:/neuro/channels/event/postponed-killam-seminar-ser
 ies-cell-types-mouse-amygdala-and-their-transcriptional-response-fear-3510
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