BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20251221T162957EST-37846KLke0@132.216.98.100 DTSTAMP:20251221T212957Z DESCRIPTION:To attend in person\, register here.\n\nTo watch via vimeo\, cl ick here.\n\n\nDavid Gosselin\n\nAssociate Professor\, Molecular Medicine\ , Université de Laval\, Canada\n\nHost: Alyson Fournier\n\nAbstract: Micro glia are the macrophages of the brain and participate to its development\, homeostasis\, and defense against pathogens and injuries. Notably\, genet ic evidence suggests that they are critically involved in neurodegenerativ e diseases\, including Alzheimer’s disease. However\, our knowledge of the molecular processes that regulate these cells and their functions in the brain remains largely incomplete.\n\nOver the past few years\, we have con centrated our efforts studying how gene regulation is achieved in microgli a\, in an effort to better understand how their functions are achieved. In particular\, we provided evidence that signaling factors present in the b rain act through the epigemome of microglia to promote their cellular iden tity. Furthermore\, our recent work identified the dominant signaling tran scriptional regulators that underlie microglial heightened immune activity in pathological conditions\, including demyelinating disorders. Notably\, our preliminary data suggests that expression of key inflammatory genes m ay be actively repressed at the chromatin/epigenetic level in microglia in the healthy brain. Thus\, their de-repression is likely to be critical to equip microglia with their full array of functions in brain lesions. My t alk will provide an overview of these recent findings\, and elaborate on t he current approaches that we use to gain a better understanding of the ep igenomic mechanisms underlying the different cellular functions of microgl ia in the brain.\n\nBio: I completed my Ph.D. in physiology-endocrinology at Université Laval in May 2012. My studies\, conducted under the supervis ion of Dr. Serge Rivest\, focused on understanding the role of pro-inflamm atory cytokine interleukin-1 beta in regulating neuronal activity in vario us brain-related pathologies. Then\, from July 2012 to March 2017\, I did a postdoctoral fellowship in epigenomics under the direction of Dr. Christ opher Glass at UC San Diego. My studies helped unravel fundamental signali ng-epigenomic mechanisms that underlie microglia cell identity. (Gosselin et al.\, Cell\, 2014\, Gosselin et al.\, Science\, 2017). Finally\, in Apr il 2017\, I was recruited at Université Laval\, where I lead a research te am at the CHU of Quebec-Laval University Research Centre dedicated to the study of the transcriptional mechanisms that underlie microglia functions in health and diseases. Our work is supported by CIHR\, MS Society of Cana da\, Alzheimer’s Society of Canada\, and the Scottish Rite Charitable Foun dation of Canada.\n\n\nSupported by the generosity of the Killam Trusts\, the MNI's Killam Seminar Series invites outstanding guest speakers whose r esearch is of interest to the scientific community at the MNI and 9IÖÆ×÷³§Ãâ·Ñ U niversity.\n DTSTART:20230425T200000Z DTEND:20230425T210000Z LOCATION:De Grandpré Communications Centre\, Montreal Neurological Institut e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University SUMMARY:Killam Seminar Series: Exploring the epigenome to decode microglial inflammatory functions URL:/neuro/channels/event/killam-seminar-series-explor ing-epigenome-decode-microglial-inflammatory-functions-342350 END:VEVENT END:VCALENDAR