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UID:20251219T145635EST-5537o6wFfC@132.216.98.100
DTSTAMP:20251219T195635Z
DESCRIPTION:Speaker: Marianna Bugiani\, MD\, PhD\n\nDepartment of Pathology
 \, Amsterdam University medical center\, Amsterdam\, the Netherlands\n\nRe
 gistration available here. \n\nAbstract: Leukodystrophies have long been d
 efined as progressive\, genetic diseases of the brain white matter\, in wh
 ich myelin is lost or is insufficiently formed\, either because of myelin 
 defects or through defects in the oligodendrocytes\, the myelin-forming ce
 lls. Currents knowledge however\, stemming from clinical and basic researc
 h\, has challenged this definition. It is now clear that genetic defects i
 n proteins expressed by any structural component of the white matter can c
 ause leukodystrophies\, including oligodendrocytes\, but also astrocytes\,
  microglia\, axons and blood vessels. Additionally\, many disease entities
  have been described in which the clinical course is not progressive\, but
  rather static or even improving over time. During my presentation\, I wil
 l provide examples of selected leukodystrophies\, also showing how neuropa
 thology can aid in the identification of the disease mechanisms. Additiona
 lly\, I will provide examples of how current treatments impact on the path
 ophysiology\, neuropathology and clinical picture.\n\n\nSupported by the g
 enerosity of the Killam Trusts \, The Neuro’s Killam Seminar series hosts 
 outstanding guest speakers whose research is of interest to the scientific
  community at The Neuro and 9IÖÆ×÷³§Ãâ·Ñ.\n
DTSTART:20211123T210000Z
DTEND:20211123T220000Z
SUMMARY:Killam Seminar Series: 'Leukodystrophies: Much More Than Just Disea
 ses of Myelin'
URL:/neuro/channels/event/killam-seminar-series-leukod
 ystrophies-much-more-just-diseases-myelin-333849
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