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UID:20251220T111413EST-5546kaVgT4@132.216.98.100
DTSTAMP:20251220T161413Z
DESCRIPTION:Speaker:  Madeline Lancaster\, Ph.D.\n\nMedical Research Counci
 l Laboratory of Molecular Biology\, Cambridge Biomedical Campus\, Cambridg
 e\, UK\n\nRegistration: available now on Eventbrite\n\nLivestreaming via V
 imeo: Vimeo\n\nAbstract: The human brain sets us apart as a species\, with
  its size being one of its most striking features. Brain size is largely d
 etermined during development as vast numbers of neurons and supportive gli
 a are generated. In an effort to better understand the events that determi
 ne the human brain’s cellular makeup\, and therefore its size\, we use a h
 uman model system in a dish\, called cerebral organoids. These 3D tissues 
 are generated from pluripotent stem cells through neural differentiation a
 nd a supportive 3D microenvironment to generate organoids with the same ti
 ssue architecture as the early human fetal brain. Such organoids are allow
 ing us to tackle questions previously impossible with more traditional app
 roaches. Indeed\, our recent findings provide insight into regulation of b
 rain size and neuron number across ape species\, identifying key stages of
  early neural stem cell expansion that set up a larger starting cell numbe
 r to enable the production of increased numbers of neurons. We are also in
 vestigating the role of extrinsic regulators in determining numbers and ty
 pes of neurons produced in the human cerebral cortex. Overall\, our findin
 gs are pointing to key\, human-specific aspects of brain development and f
 unction\, that have important implications for neurological disease.\n\nBi
 o: Dr Madeline Lancaster is a Group Leader in the Cell Biology Division of
  the Medical Research Council Laboratory of Molecular Biology (LMB)\, part
  of the Cambridge Biomedical Campus in Cambridge\, UK. Madeline studied bi
 ochemistry at Occidental College\, Los Angeles\, USA\, before completing a
  PhD in 2010 in biomedical sciences at the University of California\, San 
 Diego\, USA. She then joined the Institute of Molecular Biotechnology of t
 he Austrian Academy of Sciences (IMBA) in Vienna\, Austria as a postdoctor
 al researcher where she developed the first cerebral organoids\, before jo
 ining the LMB in 2015.\n\nResearch in the Lancaster lab focuses on human b
 rain development using stem cells to generate brain organoids that allow m
 odelling of human brain development in vitro. The laboratory studies the m
 ost fundamental differences between human brain development and that of ot
 her mammalian species. The lab also studies cellular mechanisms underlying
  neurodevelopmental disorders such as autism and intellectual disability.
 \n\n\nSupported by the generosity of the Killam Trusts \, The Neuro’s Kill
 am Seminar series hosts outstanding guest speakers whose research is of in
 terest to the scientific community at The Neuro and 9I���������.\n\n
 \nHow to participate via Zoom:\n\n1. You can either join a meeting via the
  invite link or the Meeting ID #.\n\n2. If you click the link it will auto
 matically bring you to the meeting. If you do not have the link and only t
 he meeting ID go to the Zoom application and click “Join a meeting” where 
 it will prompt you to input your name and the Meeting ID #.\n\n3. Use the 
 toolbar at the bottom of your screen to mute/unmute yourself and to enable
 /disable your video.\n
DTSTART:20210615T200000Z
DTEND:20210615T210000Z
SUMMARY:Killam Seminar Series: 'Examining human brain expansion through the
  lens of neural organoids'
URL:/neuro/channels/event/killam-seminar-series-examin
 ing-human-brain-expansion-through-lens-neural-organoids-331443
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