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UID:20250813T191841EDT-1774TjvPPo@132.216.98.100
DTSTAMP:20250813T231841Z
DESCRIPTION:9IÖÆ×÷³§Ãâ·Ñ's Seminar Series in Quantitative Life Sciences and Medic
 ine\n	Sponsored by CAMBAM\, QLS\, MiCM and the Ludmer Centre\n	 \n\nTitle: U
 nconventional NMDA Receptor Signalling in Neocortical Plasticity\n	Speaker:
  Jesper Sjostrom\, 9IÖÆ×÷³§Ãâ·Ñ\n	When: Tuesday\, January 28\, 12-1pm 
 \n	Where: Montreal Neurological Institute\, deGrandpre Communications Centr
 e\n\nAbstract: In the classical view\, postsynaptic NMDA receptors (NMDARs
 ) trigger Hebbian plasticity via calcium influx. However\, unconventional 
 presynaptic NMDARs (preNMDARs) which regulate both long-term and short-ter
 m plasticity at several synapse types have also been found. A lack of suff
 iciently specific experimental manipulations and a poor understanding of h
 ow preNMDARs signal have contributed to long-standing controversy surround
 ing these receptors. Our recent work indicates that\, whereas ionotropic p
 reNMDARs signaling controls evoked release\, spontaneous release is regula
 ted by metabotropic NMDAR signaling. Elucidating unconventional NMDAR sign
 aling modes — both presynaptically and metabotropically — is in other word
 s key to a full understanding of NMDAR function in health as well as disea
 se.\n
DTSTART:20200128T170000Z
DTEND:20200128T180000Z
LOCATION:deGrandpre Communications Centre\, 3801 rue University\, Montreal\
 , QC\, H3A 2B4\, CA\, Montreal Neurological Institute\, CA\, QC\, Montreal
 \, H3A 2B4\, 3801 rue University
SUMMARY:Unconventional NMDA Receptor Signalling in Neocortical Plasticity
URL:/micm/channels/event/unconventional-nmda-receptor-
 signalling-neocortical-plasticity-304048
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