BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20251130T155427EST-3723O8Ve4b@132.216.98.100 DTSTAMP:20251130T205427Z DESCRIPTION:This annual lecture honours Dr. Albert Aguayo\, OC\, FRCP\, Pro fessor Emeritus founder and former Director of the Centre for the Research in Neuroscience at 9I. György Buzsáki\, M.D.\, Ph.D. at NY U Neuroscience Institute will deliver a talk entitled\, 'Do you remember? Let me explain you how.'\n\n\nRegistration coming soon.\n\n\nDo You Rememb er? Let Me Explain You How.\n\nTalk Abstract: A general wisdom is that onl y selected aspects of our experiences are remembered. Extensive work over the past decades has shown that sleep plays a critical role in the consoli dation process of memory. We identified a brain pattern\, known as sharp w ave-ripple (SPW-R)\, that supports the “replay” of waking experience in co mpressed snippets (~100 ms) in the hippocampal-neocortical circuits. SPW-R s evolved in evolution to support body functions\, such as regulating gluc ose levels and hormone release\, and we exapted to serve cognitive functio ns\, parallel with the development of the neocortex. SPW-Rs are present in the resting and waking brain\, and these compressed information packages repeat fragments of learned information 2000 to 4000 times each night duri ng non-REM sleep. However\, brain mechanisms that select experiences for l asting memory are not known. To address the selection (or “credit assignme nt”) problem\, we combined large-scale neural recordings with a novel appl ication of dimensionality-reduction techniques in rodents. When the brain state changed from theta oscillations during maze exploration to SPW-Rs du ring reward consumption\, the spike content of SPW-Rs decoded the trial in which they occurred. In turn\, during post-experience sleep\, SPW-Rs cont inued to replay those trial contents that were reactivated most frequently during waking SPW-Rs. These findings demonstrate that the replay content of awake SPW-Rs provides a tagging mechanism to select critical aspects of experience that are consolidated and preserved for future use during slee p. In related experiments\, we aborted or prolonged SPW-Rs by closed-loop optogenetic methods and demonstrated impaired and enhanced memory of the p revious experience\, respectively. Thus\, SPW-Rs provide a hippocampal mec hanism for prioritizing and tagging aspects of experience and consolidatin g them during post-learning sleep.\n\nGyörgy Buzsáki\n\n\n\nGyörgy Buzsáki is Biggs Professor of Neuroscience at New York University. His main focus is “neural syntax”\, i.e.\, how the numerous brain rhythms organize segme ntation of neural information to support cognitive functions. He is among the top 0.1% of most-cited neuroscientists and an elected member of the Na tional Academy of Sciences USA\, Academiae Europaeae\, and the Hungarian A cademy of Sciences. He sits on the editorial boards of several leading neu roscience journals\, including Science and Neuron\, honoris causa at Unive rsité Aix-Marseille\, France and University of Kaposvar\, Hungary and Univ ersity of Pécs\, Hungary. He is a co-recipient of the 2011 Brain Prize and the recipient of the 2020 Ralph Gerard Award (SFN). (Books: G. Buzsáki\, Rhythms of the Brain\, Oxford University Press\, 2006\; The Brain from Ins ide Out\, OUP\, 2019)\n\nThis event is generously supported by the Rose Wi selberg Foundation.\n DTSTART:20260427T200000Z DTEND:20260427T210000Z LOCATION:de Grandpre Communications Centre\, The Neuro SUMMARY:Albert Aguayo Lecture: Do You Remember? Let Me Explain You How. URL:/medhealthsci-gradstudies/channels/event/albert-ag uayo-lecture-do-you-remember-let-me-explain-you-how-367445 END:VEVENT END:VCALENDAR