BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250707T004341EDT-2875AtsGrT@132.216.98.100 DTSTAMP:20250707T044341Z DESCRIPTION:\n \n Title: Imaging and Clinical Biomarker Estimation in Alzheim er’s Disease\n\n  \n \n\n Abstract:\n\n Estimation of biomarkers related to di sease classification and modeling of its progression is essential for trea tment development for Alzheimer’s Disease (AD). The task is more daunting for characterizing relatively rare AD subtypes such as the early-onset AD. In this talk\, I will describe the Longitudinal Alzheimer’s Disease Study (LEADS) intending to collect and publicly distribute clinical\, imaging\, genetic\, and other types of data from people with EOAD\, as well as cogn itively normal (CN) controls and people with early-onset non-amyloid posit ive (EOnonAD) dementias. I will discuss manifold estimation methods for es timation of surfaces of shapes in the brain using data clouds\, longitudin al manifold learning methods for modeling trajectories of shape changes in the brain over time. Finally\, I will discuss our work in leveraging magn etic resonance imaging and positron emission tomography data to characteri ze distributions of white matter hyperintensities in people with EOAD and to obtain imaging-based biomarkers of disease trajectories of AD subtypes. \n\n Speaker\n\n Dr. Ani Eloyan is associate professor and vice chair of Bio statistics at Brown University. Before joining the faculty at Brown\, she was a postdoctoral fellow and faculty member in the Department of Biostati stics at the Bloomberg School of Public Health\, at Johns Hopkins Universi ty. Dr. Eloyan works on developing statistical methods for analyzing medic al imaging data. She received her PhD in Statistics from North Carolina St ate University in 2010\, where she worked on the development of likelihood -based semi-parametric models for independent component analysis\, includi ng a density estimation method with moment constraints. She served on edit orial boards of the Journal of American Statistical Association and Biosta tistics as Associate Editor.\n\n https://mcgill.zoom.us/j/85422946487\n\n Me eting ID: 854 2294 6487\n\n Passcode: None\n\n DTSTART:20240119T203000Z DTEND:20240119T213000Z LOCATION:Room 1104\, Burnside Hall\, CA\, QC\, Montreal\, H3A 0B9\, 805 rue Sherbrooke Ouest SUMMARY:Ani Eloyan (Brown University) URL:/mathstat/channels/event/ani-eloyan-brown-universi ty-354278 END:VEVENT END:VCALENDAR