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UID:20250918T143429EDT-4975jBWB52@132.216.98.100
DTSTAMP:20250918T183429Z
DESCRIPTION:Title: How is cell diversity generated during development?\n\nA
 bstract: Cell cycle duration changes dramatically during development\, sta
 rting out fast to generate cells quickly and slowing down over time as the
  organism matures. The cell cycle can also act as a transcriptional filter
  to control the expression of long gene transcripts\, which are partially 
 transcribed in short cycles. Using mathematical simulations of cell prolif
 eration\, we identify an emergent property that this filter can act as a t
 uning knob to control gene transcript expression\, cell diversity\, and th
 e number and proportion of different cell types in a tissue. Our predictio
 ns are supported by comparison to single-cell RNA-seq data captured over e
 mbryonic development. Additionally\, evolutionary genome analysis shows th
 at fast-developing organisms have a narrow genomic distribution of gene le
 ngths while slower developers have an expanded number of long genes. Our r
 esults support the idea that cell cycle dynamics may be important across m
 ulticellular animals for controlling gene transcript expression and cell f
 ate.\n\n \n\nSéminaire CAMBAM Seminar Series\n	En ligne/Web - https://mcgil
 l.zoom.us/j/85428056343\n
DTSTART:20220125T170000Z
DTEND:20220125T180000Z
SUMMARY:Gary Bader\, University of Toronto
URL:/mathstat/channels/event/gary-bader-university-tor
 onto-336445
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