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UID:20250819T153931EDT-7970gKM0iG@132.216.98.100
DTSTAMP:20250819T193931Z
DESCRIPTION:Title: Emulating Target Trials to Study the Effect of Lung Tran
 splantation on Survival in Cystic Fibrosis.\n\nAbstract: Ruth is Professor
  of Biostatistics & Epidemiology at the London School of Hygiene & Tropica
 l Medicine (Medical Statistics Department and Centre for Statistical Metho
 dology). Her research focuses on the development and application of statis
 tical causal inference methods for answering questions about the effects o
 f treatments on health outcomes using observational data from patient regi
 stries and electronic health records. She is particularly focusing on appl
 ications in the area of cystic fibrosis. Ruth is funded by a UK Research a
 nd Innovation Future Leaders Fellowship.\n	\n	Link to website: https://www.l
 shtm.ac.uk/aboutus/people/keogh.ruth\n\n\nCystic fibrosis (CF) is a life-s
 hortening conditioning affecting around 10\,500 people in the UK\, and lun
 g transplantation is an option for people with CF who have end-stage lung 
 disease. Making decisions about transplant is difficult and there is a lac
 k of information about its benefits\, as randomized trials in this area ar
 e infeasible. Therefore\, understanding the impact of transplant on surviv
 al relies on observational data such as national transplant registers. I w
 ill discuss the use of “target trials” to articulate different causal ques
 tions about the effects of transplantation and discuss how to emulate the 
 target trials using observational longitudinal data on patient measures\, 
 transplant status\, and survival. Causal questions include what the effect
  is of joining the transplant wait-list and what the effect of transplant 
 is in those who received one. I will present some preliminary results base
 d on data from the UK Cystic Fibrosis Registry and discuss plans for enhan
 cing this work by making use of additional data sources.\n\nVia Zoom: http
 s://mcgill.zoom.us/j/85978187693?pwd=WWtJZUpnb0JXK3o5SStnOFcxK3FFUT09\n\nW
 eb site : www.mcgill.ca/epi-biostat-occh/news-events/seminars/biostatistic
 s\n
DTSTART:20211117T203000Z
DTEND:20211117T213000Z
SUMMARY:Ruth Keogh\, DPhil (London School of Hygiene & Tropical Medicine)
URL:/mathstat/channels/event/ruth-keogh-dphil-london-s
 chool-hygiene-tropical-medicine-334661
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