BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250813T234056EDT-2619LB75xw@132.216.98.100 DTSTAMP:20250814T034056Z DESCRIPTION:Title: Pharmacometrics is biostatistics\, sort of ?\n\nAbstract : Benjamin Rich is a pharmacometrics consultant at Certara. He uses modeli ng and simulation to help clients\, from small biotech startups to large p harmaceutical companies\, with strategic decision making and model-informe d drug development\, most notably in the areas of oncology and rare diseas es. He obtained his PhD in Biostatistics from 9I in 2012.Ph armacometrics is an interdisciplinary field at the crossroads of quantitat ive clinical pharmacology\, statistics and mathematical modeling. It is in creasingly recognized as an important component of the drug development an d regulatory approval process. In contrast to the more empirical models ty pically used in epidemiology\, for instance\, pharmacometric models tend t o be based on pharmacological or physiological principals and are often de scribed as “semimechanistic”. At the core of phamacometrics is the charact erization of drug concentration time-course by a type of nonlinear mixed-e ffects model referred to as a “population pharmacokinetic” model\, from wh ich various continuous exposure metrics can be derived. The model can help to identify sources of variability that could have an impact of dosing re commendations (e.g. renal impairment)\, and can be leveraged in simulation s to inform dose selection in special populations\, e.g. pediatrics. Ultim ately\, the goal is to link drug exposure to biochemical and clinical resp onses\, both desired and undesired\, to elucidate the drug’s risk-benefit profile\, make go/no go decisions\, design future trials and select an opt imal dosing regimen. In this talk I will give an overview of pharmacometri c concepts and present several examples.\n DTSTART:20190918T193000Z DTEND:20190918T203000Z LOCATION:Room 24\, Purvis Hall\, CA\, QC\, Montreal\, H3A 1A2\, 1020 avenue des Pins Ouest SUMMARY:Benjamin Rich\, Certara URL:/mathstat/channels/event/benjamin-rich-certara-300 751 END:VEVENT END:VCALENDAR