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UID:20250729T063909EDT-5344URWPVd@132.216.98.100
DTSTAMP:20250729T103909Z
DESCRIPTION:Title: Predictive and reconstructive modelling for rare disease
  etiology: demystifying disordered hemato-immune interactions during cycli
 c thrombocytopenia\n\nAbstract: Our understanding of how blood cells are p
 roduced and function and how the hematopoietic and immune systems are alte
 red during pathogenesis impacts directly on our ability to diagnose and tr
 eat serious hemato-immune diseases. When dysregulation occurs within the h
 emato-immune hierarchy\, a variety of serious pathologies may ensue. A num
 ber of hemato-immune disorders\, including the rare oscillatory disease cy
 clic thrombocytopenia (periodic fluctuations in megakaryocyte and platelet
  numbers\, and thrombopoietin\, the principal cytokine regulating thrombop
 oiesis) results from communication breakdowns and dysfunctionality within 
 regulatory cytokine networks. In some cases\, diseases arise from specific
  mutations\, however some healthy individuals can carry mutations without 
 impact to their health\, while others have the disease in absence of mutat
 ion. Unfortunately\, broadly speaking\, how hemato-immune disorders arise 
 and the consequences of disrupted or broken cytokine networks remains poor
 ly understood.\n	Here I will discuss two methodologies - predictive modelli
 ng using delay-differential equations and reconstructive modelling using c
 onvergent cross-mapping\, a dynamical systems technique - to understand th
 e mechanisms driving cyclic thrombocytopenia\, and to identify causal\, dy
 namic relationships between the cells and cytokines interacting within hem
 ato-immune regulatory circuits.\n
DTSTART:20190318T200000Z
DTEND:20190318T210000Z
LOCATION:Room 1104\, Burnside Hall\, CA\, QC\, Montreal\, H3A 0B9\, 805 rue
  Sherbrooke Ouest
SUMMARY:Morgan Craig (Université de Montréal)
URL:/mathstat/channels/event/morgan-craig-universite-d
 e-montreal-295392
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