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UID:20250712T081410EDT-8132fkuBIZ@132.216.98.100
DTSTAMP:20250712T121410Z
DESCRIPTION:Title:Linking a Dose-Response Model to Observed Infection to De
 scribe Spatial-Temporal Patterns in a Q Fever Outbreak\n\nAbstract: Lance 
 A. Waller\, Ph.D. is a Professor in the Department of Biostatistics and Bi
 oinformatics\, Rollins School of Public Health\, Emory University. He is a
  member of the National Academy of Science Board on Mathematical Sciences 
 and Analytics and has served on National Academies Committees on applied a
 nd theoretical statistics\, cancer near nuclear facilities\, geographic as
 sessments of exposures to Agent Orange\, and standoff explosive technologi
 es.  His research involves the development of statistical methods for geog
 raphic data including applications in environmental justice\, epidemiology
 \, disease surveillance\, spatial cluster detection\, conservation biology
 \, and disease ecology.  His research appears in biostatistical\, statisti
 cal\, environmental health\, and ecology journals and in the textbook Appl
 ied Spatial Statistics for Public Health Data (2004\, Wiley). We explore a
  Netherlands outbreak of Q fever in 2009 by combining a human dose–respons
 e model with geostatistics to predict local probability of infection\, ass
 ociated probability of illness\, and local effective exposures to Coxiella
  burnetii. We begin with the spatial distribution of 220 notified cases in
  the at–risk population.  Next\, we use the dose-response relationship (es
 tablished via historical experiments) to convert the observed risk map int
 o an estimated smooth spatial field of local dose. The estimated peak leve
 ls of exposure extend to the north–east from the point source with an incr
 easing proportion of asymptomatic infections further from the source.  Our
  work combines established methodology from model-based geostatistics and 
 dose–response modeling providing a novel approach to study outbreaks. Such
  predictions (and associated uncertainties) are important for targeting in
 terventions during an outbreak\, estimating future disease burden\, and pl
 anning public health response.\n
DTSTART:20190128T210000Z
DTEND:20190128T220000Z
LOCATION:Room 521\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y
 6\, 3655 promenade Sir William Osler
SUMMARY:LANCE A. WALLER\, PhD\, Rollins School of Public Health-Emory Unive
 rsity
URL:/mathstat/channels/event/lance-waller-phd-rollins-
 school-public-health-emory-university-293714
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