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UID:20250712T071215EDT-9586zPRLbi@132.216.98.100
DTSTAMP:20250712T111215Z
DESCRIPTION:Title:Global Measures for Capacity of Subgroup-Defining Variabl
 es to Yield Efficient Treatment Rules\n\nAbstract: Mohsen is an epidemiolo
 gist who is interested in the application of decision theory in Precision 
 Medicine. He runs the Respiratory Evaluation Sciences Program where he app
 lies such methods in the context of chronic respiratory conditions. For hi
 s work he has received multiple awards including The Canadian Institutes o
 f Health Research’s New Investigator Award and Michael Smith Foundation fo
 r Health Research Scholar Award. A fuller bio is available at http://resp.
 core.ubc.ca/team/Mohsen_SadatsafaviDecision theory provides a consistent f
 ramework for efficient treatment selection. Nevertheless\, a full applicat
 ion of decision theory requires context-specific valuations that might be 
 impractical or even off-putting in many fast-paced areas such as Precision
  Medicine. As such\, a potential way forward is to apply such principles t
 o agreed-upon ‘salient’ clinical outcomes while letting more nuanced valua
 tions to take place over their due course. We are motivated by solutions t
 o a similar problem in (bio)marker discovery: at early stages of marker de
 velopment\, the interest is\, appropriately\, on the global discriminatory
  capacity of the marker rather than its performance given a specific posit
 ivity rule. This is perhaps why AUC has remained such a popular metric for
  communicating marker performance. The purpose of this work is to propose 
 novel\, global\, ‘AUC-type’ metrics that quantify the capacity of subgroup
 -defining variables in finding individuals who benefit the most from treat
 ments. The proposed metrics have intuitive interpretations and enable comp
 arison of arbitrary sets of covariates on the same scale. They can be esti
 mated with relative ease for a wide class of regression models and can acc
 ompany conventional metrics for subgroup analysis when reporting the resul
 ts of clinical trials. • This work is developed in collaboration with Paul
  Gustafson\, The University of British Columbia\, and Mohammad Mansournia\
 , Tehran University of Medical Sciences.\n
DTSTART:20190115T203000Z
DTEND:20190115T213000Z
LOCATION:Room 24\, Purvis Hall\, CA\, QC\, Montreal\, H3A 1A2\, 1020 avenue
  des Pins Ouest
SUMMARY:Mohsen Sadatsafavi (University of British Columbia)
URL:/mathstat/channels/event/mohsen-sadatsafavi-univer
 sity-british-columbia-293081
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