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UID:20250703T074801EDT-9157ZINJMI@132.216.98.100
DTSTAMP:20250703T114801Z
DESCRIPTION:\n	Title: Bayesian Variable Selection for Multi-Dimensional Semi
 parametric Regression Models\n\n\n \n\nAbstract:\n\nHumans are routinely e
 xposed to mixtures of chemical and other environmental factors\, making th
 e quantification of health effects associated with environmental mixtures 
 a critical goal for establishing environmental policy sufficiently protect
 ive of human health. The quantification of the effects of exposure to an e
 nvironmental mixture poses several statistical challenges. It is often the
  case that exposure to multiple pollutants interact with each other to aff
 ect an outcome. Further\, the exposure-response relationship between an ou
 tcome and some exposures\, such as some metals\, can exhibit complex\, non
 linear forms\, since some exposures can be beneficial and detrimental at d
 ifferent ranges of exposure. To estimate the health effects of complex mix
 tures we propose sparse tensor regression\, which uses tensor products of 
 marginal basis functions to approximate complex functions. We induce spars
 ity using multivariate spike and slab priors on the number of exposures th
 at make up the tensor factorization. We allow the number of components req
 uired to estimate the health effects of multiple pollutants to be unknown 
 and estimate it from the data. The proposed approach is interpretable\, as
  we can use the posterior probabilities of inclusion to identify pollutant
 s that interact with each other. We illustrate our approach's ability to e
 stimate complex functions using simulated data\, and apply our method to a
  study of the association between exposure to metal mixtures and neurodeve
 lopment.\n\n \n
DTSTART:20171206T190000Z
DTEND:20171206T200000Z
LOCATION:Room 25\, Purvis Hall\, CA\, QC\, Montreal\, H3A 1A2\, 1020 avenue
  des Pins Ouest
SUMMARY:Joseph Antonelli\, PhD  Postdoctoral Fellow  Department of Biostati
 stics  Harvard University 
URL:/mathstat/channels/event/joseph-antonelli-phd-post
 doctoral-fellow-department-biostatistics-harvard-university-283109
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