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UID:20251216T074451EST-2506a8EsDv@132.216.98.100
DTSTAMP:20251216T124451Z
DESCRIPTION:You are cordially invited to attend the seminar of Dr. Sarah Bu
 ddenborg\, a candidate for the tenure-track position of Assistant Professo
 r in One Health Against Pathogens in the Institute of Parasitology.\n\nTit
 le: Helminthology in the Genomics Era\n\nParasitic worms (helminths) infec
 t over 1.5 billion people and countless animals worldwide. In humans\, chr
 onic helminth infections can cause debilitating diseases in the poorest an
 d most neglected communities\, contributing to sustaining poverty. In anim
 als\, they cause significant disease and death\, reducing productivity and
  imposing a substantial economic burden. Currently\, the only effective st
 rategy for control is through the recurrent large-scale administration of 
 anthelmintic drugs. However\, extensive overuse and mismanagement of anthe
 lmintics for nematode infections have resulted in the rapid and widespread
  development of resistance. As such\, there is an urgent need to identify 
 new therapeutics with a One Health approach to reduce dependency on any on
 e control method\, ensuring the sustainability of livestock farming and im
 proving human and animal health.\n\nRecent advances in helminth genomics o
 ffer an opportunity to understand helminth biology and identify new target
 s for control. The manually curated\, chromosome-scale genome and transcri
 ptome of the human-infecting helminth Schistosoma mansoni\, are invaluable
  resources for understanding the biology and sex-specific development of s
 chistosomes and for interpreting genomic and functional studies. Developin
 g\, optimising\, and applying powerful modern genomic techniques like sing
 le-nuclei and spatial transcriptomics to the most common gastrointestinal 
 helminth of small ruminants\, Haemonchus contortus\, reveals sex- and stag
 e-specific cell clusters. Ultimately\, this data can be used to characteri
 se the molecular mechanisms underpinning helminth success\, like environme
 ntal resilience\, drug resistance\, molting\, exsheathing\, reproduction\,
  and sexual differentiation to develop novel strategies for helminth contr
 ol.\n\nAbout the speaker\n\nSarah Buddenborg\n\nCandidate for the Assistan
 t Professor Position\, One Health Against Pathogens\n\nSarah is a classica
 lly trained parasitologist who uses both molecular and computational tools
  to understand the developmental biology of helminths of human and veterin
 ary importance.\n\nSarah is a Senior Postdoctoral Fellow in the Helminth G
 enomics group led by Steve Doyle at the Wellcome Sanger Institute in the U
 K. Currently\, Sarah is leading the development of single-cell and spatial
  transcriptomic approaches to understand the biology and life cycle of Hae
 monchus contortus\, an economically important pathogen of small ruminants.
 \n\nPrior to this\, Sarah was a Postdoctoral Fellow in the Parasite Genomi
 cs group led by Matt Berriman at the Sanger Institute. Sarah led the gener
 ation of the comprehensive transcriptome and chromosome-scale genome assem
 bly of Schistosoma mansoni\, a human-infecting helminth that causes the ne
 glected tropical disease schistosomiasis.\n\nSarah received her PhD in Bio
 logy from Sam Loker’s lab at the University of New Mexico\, where she stud
 ied snail-schistosome transcriptomics in field-derived samples.\n
DTSTART:20250609T160000Z
DTEND:20250609T170000Z
LOCATION:3-048\, Raymond Building\, CA\, QC\, St Anne de Bellevue\, H9X 3V9
 \, 21111 Lakeshore Road
SUMMARY:Recruitment Seminar: Assistant Professor in One Health Against Path
 ogens (OHAP) in the Institute of Parasitology
URL:/macdonald/channels/event/recruitment-seminar-assi
 stant-professor-one-health-against-pathogens-ohap-institute-parasitology-3
 65638
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