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UID:20250712T162415EDT-40828iuM94@132.216.98.100
DTSTAMP:20250712T202415Z
DESCRIPTION:Abstract:  A basic tenet of statistical genetics is that shared
  ancestry underlies population associations between complex traits and gen
 etic markers such as haplotypes. The coalescent is a popular mathematical 
 model of the ancestral tree of copies of a genetic locus sampled from the 
 population. While these ancestral trees cannot be observed directly\, the 
 observed haplotype data enable sampling from their posterior distribution.
  For each sampled tree\, statistical tests of shared ancestry among extrem
 e phenotypes may be applied to summarize the trait association. The distri
 bution of p-values from these association tests is a fuzzy p-value\, as de
 fined by Thompson and Geyer. This talk will review some basic ideas behind
  association fine-mapping of complex trait loci and discuss the utility of
  coalescent ancestries and fuzzy p-values in this regard. I will present s
 ome preliminary results from ongoing experiments with these ideas on an ex
 ample dataset of 125 cases and 125 controls defined by an immune marker pr
 edictive for type 1 diabetes. This is joint work with Kelly Burkett and Br
 ad McNeney.   pp  Bio:  Jinko Graham is an Associate Professor of Statisti
 cs and Actuarial Science and a member of the Statistical Genetics Working 
 Group at Simon Fraser University. Her research is directed towards the dev
 elopment of statistical methods for inference from genetic data\, with a f
 ocus on genetic association studies. One question of interest is incorpora
 ting the gene genealogies underlying genotypes at multiple markers to map 
 the genomic location of traits under genetic influence. Another question i
 s the unbiased display and inference of statistical interaction between ge
 nes and the environment in complex diseases of early onset\, using data fr
 om cases and their parents. Much of her research involves complex data str
 uctures and so has a strong computational component. Dr. Graham is enjoyin
 g time in Montreal\, working with Dr. Celia Greenwood and colleagues.  
DTSTART:20130129T210000Z
DTEND:20130129T220000Z
SUMMARY:Biostatistics Seminar - Dr Jinko Graham - A test drive of haplotype
 -informed ancestries for fine mapping complex genetic traits.
URL:/epi-biostat-occh/channels/event/biostatistics-sem
 inar-dr-jinko-graham-test-drive-haplotype-informed-ancestries-fine-m
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