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UID:20250710T030749EDT-99456IusPt@132.216.98.100
DTSTAMP:20250710T070749Z
DESCRIPTION:This is a reminder that all students\, faculty and post-doctora
 l fellows are invited to participate in the new EBOH Applied Methods Discu
 ssion Group.\n\nThe objective of this group is to give us an opportunity t
 o address and discuss real methodological challenges in our area of practi
 ce. The goal of each session will be to tackle one methodological challeng
 e (or a small number of related challenges) that we encountered in our res
 earch\, all the while putting a strong emphasis on the application and the
  implementation of related methods to overcome this problem. The group is 
 intended to be student-run and student-led for the most part.\n\nThe first
  meeting is to take place on April 1st from 12-1pm in Purvis Room 24 where
  Dr. Aman Verma will share a current challenge in developing a study desig
 n to assess epinephrine dose given by paramedics and brain damage outcomes
  (see below for more details).\n\nRefreshments will be served! \n\nIf you 
 have any questions or have an interest in sharing a methods related issue 
 at a later date\, please feel free to contact Daniala Weir (daniala.weir [
 at] mail.mcgill.ca)\, Helen Cerigo (helen.cerigo [at] mail.mcgill.ca)\, Br
 uno Riverin (Bruno.riverin [at] mail.mcgill.ca) or Maxime Turgeon (maxime.
 turgeon [at] mail.mcgill.ca).\n\nThanks\,\n\nDaniala\, Helen\, Bruno and M
 axime\n\nEpinephrine and the Survival Bias\n\nContext: Urgence Santé is th
 e organization in Quebec that runs\, among other things\, the ambulances. 
 They have done some small research projects in the past\, but they are loo
 king to increase their research profile. They believe that they need to do
  an experimental trial to be taken seriously\, and have settled on a topic
  of interest (the effect of epinephrine on brain damage)\, and have asked 
 for help with calculating statistical power.\n	Study Question: We know that
  epinephrine\, given by the paramedics at the time of “pick up”\, increase
 s survival-to-hospital\, but we also suspect that it increases the probabi
 lity of brain damage (by the time they are discharged). We want to know if
  a lower dose of epinephrine will decrease the probability of brain damage
 .\n	\n	Study Design: Urgence Santé proposes that we do a randomized\, contro
 lled trial in which both arms of patients are given different doses of the
  epinephrine\, and we compare the rate of brain damage in both groups.\n	\n
 	Design issues: The design is complicated by the “two-phase” nature of the 
 outcome: survival-to-hospital must occur for brain damage to occur. If a l
 ower dose of epinephrine does not decrease the risk of brain damage\, but 
 it does decrease the rate of survival-to-hospital in those who would have 
 got brain damage\, then it would look like the lower dose decreases the ri
 sk of brain damage.\n	\n	Solutions?: Urgence Santé needs help in designing a
  study to get an unbiased estimate of the effect of the lower dose of epin
 ephrine on brain damage. They welcome observational designs\, but also wan
 t results that can be clearly explained to field staff. \n
DTSTART:20160401T160000Z
DTEND:20160401T170000Z
LOCATION:Room 24\, Purvis Hall\, CA\, QC\, Montreal\, H3A 1A2\, 1020 avenue
  des Pins Ouest
SUMMARY:New! EBOH Applied Methods Discussion Group
URL:/epi-biostat-occh/channels/event/new-eboh-applied-
 methods-discussion-group-260000
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