BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250803T013309EDT-5863rsHv0I@132.216.98.100 DTSTAMP:20250803T053309Z DESCRIPTION:Olga Basso\, PhD\n\nAssociate Professor\, Department of Obstetr ics & Gynecology and the Department of Epidemiology\, Biostatistics & Occu pational Health\, 9IÖĆ×÷ł§Ăâ·Ń\n\nImplications of using a fetuses-at- risk approach when fetuses are not at risk\n\nMonday\, 5 October 2015\n\n4 :00 pm - 5:00 pm – McIntyre Medical Building\n\n3655 promenade Sir William Osler – Meakins – Rm 521\n\nALL ARE WELCOME\n\nSYNOPSIS:\n\nIt is accepte d that fetuses\, not babies\, are at risk of antepartum stillbirth\; howev er\, several studies examine the gestational-age- specific rates of postna tal endpoints (such as neonatal death) using fetuses as the denominator\, rather than live births. Such fetuses-at-risk (FAR) approaches are appeali ng because many of the events relevant for infant health occur during pren atal life\, and gestational time is treated as time at risk. FAR analyses also generally avoid “paradoxes” often seen when using births as the denom inator\, whereby exposures that are overall harmful appear protective at p reterm weeks. Advocates of extending the FAR approach to encompassing post natal outcomes claim that it provides a causal framework for perinatal epi demiology\, in contrast with the “conventional” formulation based on live births at each week. Using simple examples\, I will show how\, when examin ing postnatal endpoints\, using fetuses as the denominator inevitably lead s to estimates that do not quite reflect the effect of length of gestation \, nor that of a given exposure\, on outcome. The broader issue of conditi oning on specific events when studying the effect of exposures in reproduc tive epidemiology will also be discussed.\n\nOBJECTIVES:\n\n\n To illustrat e the difference between the types of denominator used in perinatal epidem iology to estimate gestational-age-specific rates of a given endpoint.\n To highlight the implications of using fetuses as the denominator for outcom es that can only be ascertained after birth\n To discuss the broader conseq uences of conditioning (or not) on specific events when measuring the effe ct of an exposure.\n\n\nBIO:\n\nOlga Basso is Associate Professor at McGil l University\, with a joint appointment at the Department of Obstetrics an d Gynecology and the Department of Epidemiology\, Biostatistics\, and Occu pational Health. Her main interest is in reproductive epidemiology\, with a focus on trying to disentangle the contributions of complex risk factors on child health.  Her work addresses both substantive and methodological issues.\n\n \n DTSTART:20151005T200000Z DTEND:20151005T210000Z LOCATION:Room 521\, Meakins\, McIntyre Medical Building\, CA\, QC\, Montrea l\, H3G 1Y6\, 3655 promenade Sir William Osler SUMMARY:Epidemiology Seminar URL:/epi-biostat-occh/channels/event/epidemiology-semi nar-255405 END:VEVENT END:VCALENDAR