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UID:20250811T200021EDT-5023hKUNv2@132.216.98.100
DTSTAMP:20250812T000021Z
DESCRIPTION:Inositol phosphates are ubiquitous intracellular molecules in e
 ukaryotes. They play important roles in essential processes such as signal
 ling. In addition\, some bacterial toxins such as the clinically relevant 
 Clostridium difficile toxin B (TcdB) utilize inositol hexakisphosphate as 
 a trigger for an intracellular auto-processing step that is important in t
 he pathogenesis. We have prepared analogues of inositol phosphate that are
  capable of inducing premature TcdB auto-processing that result in inactiv
 e toxin. These molecules constitute an exciting therapeutic avenue against
  this alarming hospital infection. We are also exploring other interesting
  properties of the inositol phosphates\, such as their strong interaction 
 with inorganic material such as calcium phosphates\, which has implication
  in drug delivery and bone targeting.\n
DTSTART:20160322T170000Z
DTEND:20160322T183000Z
LOCATION:Rm 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 
 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Inositol Phosphate Analogues Play a Trick
  on a C. difficile toxin\, Dr. Bastien Castagner
URL:/chemistry/channels/event/chemical-society-seminar
 -inositol-phosphate-analogues-play-trick-c-difficile-toxin-dr-bastien-2575
 68
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