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UID:20250821T111846EDT-2898g8sIBt@132.216.98.100
DTSTAMP:20250821T151846Z
DESCRIPTION:The chemical synthesis of proteins is critical to the understan
 ding of biological function of proteins\, particularly those containing po
 sttranslational modifications or involved in covalent protein–protein conj
 ugates. In order to expand the scope of chemical protein synthesis and to 
 improve the ease with which proteins can be chemically synthesis\, our gro
 up has sought to identify new ligation reactions that give native peptide 
 bonds under mild\, chemoselective conditions.  This work has led to the di
 scovery of the alpha-ketoacid–hydroxylamine amide-forming (KAHA) ligation\
 , which operates in the presence of unprotected functional groups\, requir
 es no reagents or catalysts\, and proceeds under aqueous conditions.\nThis
  talk will describe the development of the KAHA ligation\, the reaction me
 chanism\, methods to prepare peptide segments containing the key functiona
 l groups\, and the application of this reaction to the chemical synthesis 
 of proteins\, including challenging targets such as membrane associated pr
 oteins. Finally\, we will discuss possible solutions to the still unsolved
  problem of ligating large\, unprotected molecules at submillimolar concen
 trations with equimolar stoichiometry.
DTSTART:20160315T170000Z
DTEND:20160315T183000Z
LOCATION:Rm 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 
 801 rue Sherbrooke Ouest
SUMMARY:Belleau Lecture: Chemical Protein Synthesis with the KAHA and KAT L
 igations\, Dr. Jeffrey Bode
URL:/chemistry/channels/event/belleau-lecture-chemical
 -protein-synthesis-kaha-and-kat-ligations-dr-jeffrey-bode-257567
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