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UID:20250811T182350EDT-2872Tlv8da@132.216.98.100
DTSTAMP:20250811T222350Z
DESCRIPTION:Sequencing of the human genome provided a wealth of information
  about the genomic blueprint of a cell. But genes do not tell the entire s
 tory of life and living processes\; identifying the roles of enzymes and m
 apping out their interactions is also crucial. Enzymes catalyze virtually 
 every cellular process and metabolic exchange. They not only are instrumen
 tal in sustaining life but also are required for its regulation and divers
 ification. Diseases such as cancer can be caused by minor changes in enzym
 e activities. In addition\, the unique enzymes of pathogenic organisms are
  ripe targets for combating infections. Consequently\, nearly one-third of
  all current drug targets are enzymes. Little\, however\, is understood ab
 out the physiological roles\, substrate specificity\, and downstream targe
 ts of the vast majority of these important proteins. A key step toward the
  biological characterization of enzymes\, as well as their adoption as dru
 g targets\, is the development of global solutions that bridge the gap in 
 understanding these proteins and their interactions. Catalomics is an emer
 ging field in chemical biology in which chemical and biological tools are 
 developed\, enabling large-scale studies of enzymes at the organism level.
  In this presentation\, I will discuss the latest progress made in my labo
 ratory in relation to drug discovery. Specifically\, I will discuss our re
 cent results on using microarray-based technologies for discovery of poten
 tial drug candidates. In addition\, I will describe our recent strategy on
  the development of small molecule chemical probes for cell-based proteome
  profiling of potential drug targets (on and off)\, and imaging applicatio
 ns. Finally\, I may talk about our recent efforts in the development of to
 ols that facilitate endocytosis-independent\, cellular delivery and contro
 lled release of bioactive molecules\, including small molecule drugs\, the
 rapeutic proteins (including antibodies) and nucleic acids.  \n
DTSTART:20150930T183000Z
DTEND:20150930T200000Z
LOCATION:Room 217\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8
 \, 801 rue Sherbrooke Ouest
SUMMARY:Special Seminar: Dr. Shao Q Yao - Recent Advances In Catalomics
URL:/chemistry/channels/event/special-seminar-dr-shao-
 q-yao-recent-advances-catalomics-255700
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