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UID:20250820T225223EDT-2084B1vGzc@132.216.98.100
DTSTAMP:20250821T025223Z
DESCRIPTION:Abstract:\n\nAberrant Wnt/β-catenin signaling drives tumorigene
 sis and metastasis of many cancers. Catalytic inhibition of tankyrase supp
 resses Wnt/β-catenin signaling by blocking the turnover of Axin that helps
  assemble the β-catenin destruction complex (DC). However\, tankyrase also
  supports Wnt/β-catenin signaling through a poorly understood mechanism of
  molecular scaffolding. Herein\, we show that catalytic inhibition of tank
 yrase induces tankyrase accumulation to augment Axin puncta formation. Thi
 s event drives a liquid-to-solid phase transition of the DC to impede the 
 turnover of β-catenin\, which potentially explains the unsatisfactory outc
 omes of drugging the Wnt/β-catenin signaling pathway by TNKSi. By contrast
 \, depleting tankyrase with PROTAC dissolves the Axin puncta without affec
 ting the DC function. As such\, it allows for a deep suppression of the Wn
 t/β-catenin pathway activity and provides a better control of the prolifer
 ation of cancer cells with dysfunctional APC mutations. Collectively\, ind
 uced degradation of tankyrase is a promising new approach to treat cancers
  driven by β-catenin.\n\n \n\nBio:\n\nChuo Chen was born and grew up in Ta
 ipei\, Taiwan\, ROC. He studied natural product synthesis under the direct
 ion of Professor Matthew Shair at Harvard University and obtained his Ph.D
 . degree in 2001. He then worked as a Howard Hughes Medical Institute post
 doctoral fellow in Professor Stuart Schreiber's laboratory at Harvard Univ
 ersity before joining the faculty of the University of Texas Southwestern 
 Medical Center in 2004. He is now a Professor in Biochemistry and a Southw
 estern Medical Foundation Scholar in Biomedical Research. Chuo has diverse
  interests in chemical and biological researches. His early career focuses
  on natural product synthesis and synthetic method development. Currently\
 , his lab uses a combination of chemical and biological tools to study the
  cGAS-STING and Wnt signaling pathways.\n
DTSTART:20221115T180000Z
DTEND:20221115T193000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Chuo Chen - Do we have a better way to st
 op Wnt now?
URL:/chemistry/channels/event/chemical-society-seminar
 -chuo-chen-do-we-have-better-way-stop-wnt-now-340123
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