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UID:20251012T023243EDT-44838N93jJ@132.216.98.100
DTSTAMP:20251012T063243Z
DESCRIPTION:Abstract:\n\nThe lipid bilayer that encases human cells has evo
 lved to keep the outside out\, and the inside in. This barrier is not\, ho
 wever\, impenetrable. Some small molecules\, including many drugs\, can bu
 rrow through and manifest therapeutic activities. Others can be “cloaked” 
 to endow membrane permeability\, and then uncloaked inside cells. We have 
 learned how to beneficially cloak proteins\, which are typically 100-fold 
 larger than small-molecule drugs. Specifically\, the use of tuned diazo co
 mpounds to convert protein carboxyl groups into esters enables a protein t
 o traverse the lipid bilayer. The nascent esters are substrates for endoge
 nous esterases that regenerate native proteins within cells. The ability t
 o deliver native proteins directly into cells opens a new frontier for mol
 ecular medicine.\n\nBio:\n\nProfessor Raines (he/him) received Sc.B. degre
 es in chemistry and biology at MIT\, performing undergraduate research wit
 h Christopher T. Walsh. He received A.M. and Ph.D. degrees in chemistry at
  Harvard University for research done with Jeremy R. Knowles. He was a Hel
 en Hay Whitney postdoctoral fellow with William J. Rutter in the Departmen
 t of Biochemistry and Biophysics at the University of California\, San Fra
 ncisco. He then joined the faculty at the University of Wisconsin–Madison\
 , where he became the Henry Lardy Professor of Biochemistry\, Linus Paulin
 g Professor of Chemical Biology\, and a Professor of Chemistry. He was a V
 isiting Associate in Chemistry at Caltech in 2009. In 2017\, he returned t
 o MIT as the Roger and Georges Firmenich Professor of Natural Products Che
 mistry\, an Extramural Member of the Koch Institute for Integrative Cancer
  Research at MIT\, and an Associate Member of the Broad Institute of MIT a
 nd Harvard.\n\nProfessor Raines is an author of over 400 peer-reviewed jou
 rnal articles\, and an inventor on more than 60 US patents. He has advised
  over 100 graduate students and postdoctorates. Alumni from his research g
 roup enjoy careers as faculty members at distinguished research universiti
 es\, medical schools\, and colleges\; and as research scientists at innova
 tive start-up companies\, leading corporations\, and government laboratori
 es.\n
DTSTART:20211005T170000Z
DTEND:20211005T183000Z
LOCATION:Room 112\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8
 \, 801 rue Sherbrooke Ouest
SUMMARY:The 2021 Clifford B. Purves Lecture: Ronald T. Raines - Ghost Prote
 ins
URL:/chemistry/channels/event/2021-clifford-b-purves-l
 ecture-ronald-t-raines-ghost-proteins-332905
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