BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250801T231514EDT-8288VLEw2A@132.216.98.100 DTSTAMP:20250802T031514Z DESCRIPTION:Zoom link:\n\n \n\nAbstract:\n\nCell penetration is a major obs tacle for developing peptide\, protein and nucleic acid therapeutics. Many commonly used techniques for measuring cell penetration are qualitative\, and most cannot distinguish cytosolic material from material trapped at t he cell surface or in endosomes. We have devised a new technique\, the chl oroalkane penetration assay (CAPA)\, that measures penetration to the cyto sol in a high-throughput\, quantitative manner. We are using CAPA in a wid e range of applications\, including: determining structure-penetration rel ationships for peptide therapeutics\, quantitating penetration into differ ent subcellular organelles and compartments\, and measuring cytosolic pene tration for a wide variety of druglike macrocycles\, peptides\, oligonucle otides\, and proteins.\n\nBio:\n DTSTART:20210907T170000Z DTEND:20210907T183000Z LOCATION:801 rue Sherbrooke O SUMMARY:Chemical Society Seminar: Joshua A. Kritzer - Cell Penetration Prof iling for Biotherapeutics URL:/chemistry/channels/event/chemical-society-seminar -joshua-kritzer-cell-penetration-profiling-biotherapeutics-332902 END:VEVENT END:VCALENDAR