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UID:20250820T104143EDT-56011uNP64@132.216.98.100
DTSTAMP:20250820T144143Z
DESCRIPTION:Zoom link: https://mcgill.zoom.us/j/85231656851\n\nAbstract:\n
 \nAdhesion molecules on cell surfaces help cells attach to their environme
 nt and transduce mechanically-coupled biochemical signal. To understand th
 e mechanical forces involved at the molecular scale\, molecular force sens
 ors have been used to probe forces at cell-substrate interfaces. Several c
 lasses of force sensors have been developed in the past 5 years including 
 the DNA-based Tension Gauge Tether (TGT). TGTs rely on the force-dependent
  dissociation of complementary dsDNA strands to probe forces where the mec
 hanical stability can be semi-quantitatively tuned by DNA sequence and pul
 ling geometry. We will provide an overview of the field to show the advant
 ages and disadvantages of different classes of current force sensors. We w
 ill then show applications of TGT in studying fast dynamic molecular adhes
 ion processes involved in cell rolling adhesion. Lastly\, we will introduc
 e a framework to quantify molecular forces using the TGTs.\n\nBio: \n\n \n
DTSTART:20201006T170000Z
DTEND:20201006T183000Z
SUMMARY:Chemical Society Seminar: Isaac Li  - Imaging molecular force with 
 DNA sensors
URL:/chemistry/channels/event/chemical-society-seminar
 -isaac-li-imaging-molecular-force-dna-sensors-320798
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