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UID:20250820T074600EDT-3670xRzEvv@132.216.98.100
DTSTAMP:20250820T114600Z
DESCRIPTION:Zoom link: https://mcgill.zoom.us/j/95809868002\n\nAbstract:\n
 \nMany reactions in organic chemistry are extremely complex\, with large m
 ultivariate parameter spaces and multiple possible mechanistic pathways. D
 uring development of synthetic routes toward investigational Active Pharma
 ceutical Ingredients (APIs)\, my group at GlaxoSmithKline used both high-t
 hroughput experimentation and reaction progress analysis in order to map a
 nd understand complex reactions. High-throughput experimentation allows fo
 r simultaneous interrogation of multiple reaction parameters\, illuminatin
 g aspects to chemical reactivity that are not apparent during traditional 
 one-variable-at-a-time experimental designs. By combining these insights w
 ith kinetic monitoring and stoichiometric reactivity\, we have been able t
 o rapidly develop and optimize many complex transformations for API synthe
 sis. Several case studies will be presented\, with an emphasis on how insi
 ghts from target-based API synthesis can lead to more general advances in 
 synthetic methodology.\n\nBio:\n\nDave was raised on Vancouver Island in P
 ort Alberni\, and conducted both his undergraduate and graduate degrees at
  the University of British Columbia. He received his PhD in 2010 under the
  direction of Prof. Laurel Schafer. After postdoctoral appointments at McG
 ill University with Prof. Bruce Arndtsen (2010-2012)\, and at the Californ
 ia Institute of Technology with Prof. John Bercaw and Dr. Jay Labinger as 
 an NSERC PDF (2012-2014)\, he migrated to industry\, holding positions in 
 pharmaceutical process chemistry R&D at GlaxoSmithKline (2014-2018). He ro
 se to the level of group leader in both catalysis and flow chemistry\, wor
 king on synthetic problems for predominantly early-phase clinical candidat
 e molecules. In January of 2019\, he returned home to Vancouver Island to 
 take up an appointment at the University of Victoria.\n
DTSTART:20200922T170000Z
DTEND:20200922T183000Z
SUMMARY:Chemical Society Seminar: David Leitch  - Developing Catalytic And 
 Flow Processes For Synthesizing Active Pharmaceutical Ingredients – Perspe
 ctives From An Industrial-Turned-Academic Chemist
URL:/chemistry/channels/event/chemical-society-seminar
 -david-leitch-developing-catalytic-and-flow-processes-synthesizing-active-
 320796
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