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VERSION:2.0
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UID:20251011T184444EDT-6172kVcc5N@132.216.98.100
DTSTAMP:20251011T224444Z
DESCRIPTION:Abstract:\n\nArtemisinin is a major antimalarial drug currently
  produced by a semi-synthetic route which involves a fermentation step and
  a key photochemical oxidation reaction. The costs associated with this pr
 ocess are currently too high to maintain a low market price and there is t
 herefore a need for more affordable\n	manufacturing routes.\n	A first soluti
 on is the optimization of the current photochemical oxidation step which i
 s low yielding. To circumvent this problem\, we have worked on the design 
 of more environmentally benign photochemical oxidations with visible light
  which rely on the adsorption of a commercial photocatalyst on silica. Thi
 s rather straightforward and inexpensive approach has enabled the discover
 y of interesting surface effects which accelerate the conversion. This imm
 obilization strategy can also be utilized to intensify photochemical oxida
 tions in a fixed bed continuous flow reactor.\n\nIn a second part\, we wil
 l present a series of alternative new semi-synthetic routes based on the v
 alorisation of amorphadiene\, a high yielding fermentation intermediate cu
 rrently treated as a waste. We will show how photochemistry can be a highl
 y cost-competitive solution to convert this compound into a key intermedia
 te of the artemisinin synthesis.\n\nBio:\n\nZacharias Amara graduated with
  a Pharmaceutical Degree in 2008 and then with a PhD in organic chemistry 
 in 2012 at the University of Paris-Sud. He then moved to the UK to work in
  green chemistry as a postdoctoral researcher at the University of Notting
 ham in the group of Pr Martyn Poliakoff and Pr Mike George. In 2015\, he r
 eturned to Paris to start his independent career as an assistant professor
  at the National Conservatory of Arts and Crafts (Engineering School). He 
 teaches organic chemistry and formulation chemistry. His interests lie in 
 the development of new catalytic transformations\, photochemistry and cont
 inuous flow processing applied to pharmaceutical synthesis. In 2017\, he r
 eceived an Ignition Grant Award from the ACS Green Chemistry Institute and
  in 2018\, a grant from the Bill and Melinda Gates Foundation to carry out
  a new research program on the development of new routes to artemisinin.\n
DTSTART:20200207T160000Z
DTEND:20200207T170000Z
LOCATION:Room 428\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8
 \, 801 rue Sherbrooke Ouest
SUMMARY:Zacharias Amara - New photochemical and non-photochemical routes to
  the antimalarial drug artemisinin
URL:/chemistry/channels/event/zacharias-amara-new-phot
 ochemical-and-non-photochemical-routes-antimalarial-drug-artemisinin-30558
 6
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