BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20251102T202405EST-3526I9upUA@132.216.98.100
DTSTAMP:20251103T012405Z
DESCRIPTION:A Staphylococcus lugdunensis isolate from the human nose was fo
 und to produce a compound with strong bactericidal activity against multi-
 resistant Staphylococcus aureus.\n	The bioactive substance was purified fro
 m the extract. Structure elucidation by 1D- and 2D-NMR\, high resolution m
 ass spectrometry\, multistage tandem mass spectrometry\, advanced Marfey’s
  analysis and tailored colour reactions revealed a mostly hydrophobic cycl
 ic heptapeptide with alternating amino acid stereoconfiguration. The thiaz
 olidine heterocycle – for the first time in a cyclopeptide – and a tryptop
 han are characteristic for the compounds with potent biological activity.
 \n\n\n	Named lugdunin A (1)\, the assigned structure of the main compound w
 as confirmed by chemical synthesis. The solid phase peptide synthesis (SPP
 S) was especially customized to form the new thiazolidine heterocycle in t
 his cycloheptapeptide. A non-ribosomal peptide synthase (NRPS) is responsi
 ble for the biosynthesis in Staphylococcus lugdunensis. With manifold prod
 ucts from our chemical synthesis\, the important SAR (structure activity r
 elationship)-studies comprise an alanine scan to assess the significance o
 f individual amino acids for biological activity. The stereo scan emphasiz
 ed the relevance of the peptide`s backbone D-\, L- stereochemistry. Notabl
 y\, the enantiomer of lugdunin A (1) is as active as lugdunin itself. Ther
 efore\, we shuffled the stereocenters and amino acids within the backbone 
 sequence and derivatized lugdunin to reveal nature’s architectural concept
  of the antibacterial agent.\n
DTSTART:20180424T170000Z
DTEND:20180424T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Stephanie Grond - Lugdunin - a new antibi
 otic from our nose: Structure\, chemical synthesis and bioactivity
URL:/chemistry/channels/event/chemical-society-seminar
 -stephanie-grond-lugdunin-new-antibiotic-our-nose-structure-chemical-28677
 7
END:VEVENT
END:VCALENDAR