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UID:20250811T195224EDT-3427PhlvkM@132.216.98.100
DTSTAMP:20250811T235224Z
DESCRIPTION:The endoplasmic reticulum (ER) is the site of synthesis of\nant
 ibodies that are either destined to be expressed on the cell\nsurface or s
 ecreted.  These proteins enter the ER through a\nprotein channel as extend
 ed polypeptide chains and interact with a\nvariety of molecular chaperones
  and folding enzymes that help them\nachieve their proper mature tertiary 
 and quaternary structures\,\nwhich in their simplest form requires the ass
 embly of two heavy and\ntwo light chains.  If successful\, the antibody le
 aves the ER\nto travel to its appropriate destination outside the cell.  I
 f\nhowever\, the nascent heavy or light chain fails to fold or assemble\np
 roperly\, it must be identified and targeted for retrotranslocation\nto th
 e cytosol for degradation by the 26S proteasome\, which\ninvolves some of 
 the same molecular chaperones.  There are a\nnumber of unresolved issues c
 oncerning how the ER quality control\nmachinery can distinguish between pr
 oteins that have not yet folded\nand those that cannot fold\, as it is exp
 ected that both types of\nproteins would have very similar features.  In a
 ddition\, the\nfolding of many nascent proteins is dependent on the oxidiz
 ing\nenvironment of the ER\, whereas the degradation of misfolded\nprotein
 s often requires that those portions of the protein that\nhave folded be r
 educed to allow them to pass through the\nretrotranslocon.  Finally\, any 
 protein that is synthesized in\nthe ER has the potential to misfold\, argu
 ing that the\nubiquitin/proteasome system must be poised to recognize ever
 y type\nof secretory pathway produced in that cell.  How such broad\nspeci
 ficity is executed remains unclear. Progress from our lab on\nthese issues
  and how this contributes to understanding how the ER\norchestrates seemin
 gly opposing functions will be presented.\n
DTSTART:20110819T180000Z
DTEND:20110819T190000Z
LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr
 omenade Sir William Osler
SUMMARY:Biochemistry Seminar - Dr. Linda Hendershot
URL:/channels/event/biochemistry-seminar-dr-linda-hend
 ershot-176259
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