BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250917T224515EDT-3919vKoTil@132.216.98.100
DTSTAMP:20250918T024515Z
DESCRIPTION:Dr. Yijun Ruan\nProfessor\nGenome Institute of Singapore\n“Chro
 matin Looping Architecture and Models of Transcription\nRegulation in Huma
 n Cancer Cells”\n \nGenomes are known to be organized into 3D structures i
 n vivo\nthrough interactions with protein factors for nuclear process such
 \nas transcription\, and DNA elements separated by long genomic\ndistances
  are known to functionally interact. However\, the details\nof this view a
 re largely unknown. To explore in this direction\, we\ndeveloped the Chrom
 atin Interaction Analysis using Paired-End-Tag\nsequencing (ChIA-PET) stra
 tegy for de novo detection of genome-wide\nchromatin interactions\, and de
 monstrated this approach through\ncomprehensive mapping of chromatin inter
 actions involved in\ntranscription regulations mediated by estrogen recept
 or α (ERα) in\na human genome. In order to map all chromatin loops that ar
 e\nimportant to chromatin architecture and gene transcription\nregulation\
 , we have applied the ChIA-PET strategy to general\nprotein factors such a
 s RNA polymerase II (RNAPII) involved in all\ntranscription activities as 
 analysis targets in a number of human\ncells. Our recent results reveal th
 at large numbers of RNAPII genes\nare organized into operon-like configura
 tion through long-range\nchromatin interactions for coordinated transcript
 ion regulation.\nFurthermore\, through CTCF ChIA-PET analysis we have disc
 overed the\nprimary role of CTCF is to confer genome-wide 3D framework of
 \nchromatin loops for nuclear functions such as transcriptional\nactivatio
 n and repression.  Further analyses of chromatin\ninteractome\, transcript
 ome\, and histone modification maps will\nprovide deep insights to advance
  our understanding of human genome\nbiology.\n \nMandatory for Biochemistr
 y Graduate Students\n
DTSTART:20101101T160000Z
DTEND:20101101T160000Z
LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr
 omenade Sir William Osler
SUMMARY:Biochemistry and Systems Biology Seminar - Dr. Yijun Ruan (Beatty L
 ecture)
URL:/channels/event/biochemistry-and-systems-biology-s
 eminar-dr-yijun-ruan-beatty-lecture-168265
END:VEVENT
END:VCALENDAR