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UID:20250817T232857EDT-0371vfRTaT@132.216.98.100
DTSTAMP:20250818T032857Z
DESCRIPTION:Dr. John Aitchison\nProfessor\nAssociate Director Institute for
  Systems Biology Seattle\nPlease Note: Dr. John Aitchison has cancelled hi
 s visit\ndue to the weather in Chicago - his flights were cancelled. \nHe 
 will be scheduling a visit and seminar at another\ntime.\n“Systems Biology
  of organelle biogenesis”\nWe exploit the model organism S. cerevisiae for
  developing\nsystems biology approaches to understand peroxisomes and pero
 xisome\nbiogenesis.  Peroxisomes are ubiquitous intracellular\norganelles 
 that perform a variety of metabolic functions\, most\nnotably fatty acid b
 eta oxidation.  Peroxisomes are remarkably\ndynamic and their biogenesis o
 ccurs in response to a variety of\nstimuli.  In yeast\, peroxisomes are dr
 amatically induced by\nfatty acids. The laboratory focuses on understandin
 g the network\ndynamics controlling this biogenesis response at multiple l
 evels\,\nincluding signaling\, transcription\, chromatin dynamics and\norg
 anelle biogenesis\, using functional genomics\, proteomics and\ncomputatio
 nal tools of molecular systems biology.\n \n \nMarelli\, M.\, Smith\, J. J
 .\, Jung\, S.\, Yi\, E.\, Nesvizhskii\, A. I.\,\nChristmas\, R. H.\, Salee
 m\, R. A.\, Tam\, Y. Y.\, Fagarasanu\, A.\,\nGoodlett\, D. R.\, Aebersold\
 , R.\, Rachubinski\, R. A. and Aitchison\,\nJ. D. (2004) Quantitative mass
  spectrometry reveals a role for the\nGTPase Rho1p in actin organization o
 n the peroxisome membrane\, J\nCell Biol\, 167: 1099-1112\nRamsey\, S. A.\
 , Smith\, J. J.\, Orrell\, D.\, Marelli\, M.\, Petersen\,\nT. W.\, de Atau
 ri\, P.\, Bolouri\, H. and Aitchison\, J. D. (2006) Dual\nfeedback loops i
 n the GAL regulon suppress cellular heterogeneity\nin yeast\, Nat Genet\, 
 38: 1082-1087\nSmith\, J. J.\, Ramsey\, S. A.\, Marelli\, M.\, Marzolf\, B
 .\, Hwang\,\nD.\, Saleem\, R. A.\, Rachubinski\, R. A. and Aitchison\, J. 
 D. (2007)\nTranscriptional responses to fatty acid are coordinated by\ncom
 binatorial control\, Mol Syst Biol\, 3: 115\nHood\, L.\, Rowen\, L.\, Gala
 s\, D. J. and Aitchison\, J. D. (2008)\nSystems biology at the Institute f
 or Systems Biology\, Brief Funct\nGenomic Proteomic\, 7: 239-248\nMarelli\
 , M.\, Nesvizhskii\, A. I. and Aitchison\, J. D. (2008)\nIdentifying bona 
 fide components of an organelle by isotope-coded\nlabeling of subcellular 
 fractions : an example in peroxisomes\,\nMethods Mol Biol\, 432: 357-371\n
 Ratushny\, A. V.\, Ramsey\, S. A.\, Roda\, O.\, Wan\, Y.\, Smith\, J. J.\n
 and Aitchison\, J. D. (2008) Control of transcriptional variability\nby ov
 erlapping feed-forward regulatory motifs\, Biophys J\, 95:\n3715-3723\nSal
 eem\, R. A.\, Knoblach\, B.\, Mast\, F. D.\, Smith\, J. J.\, Boyle\,\nJ.\,
  Dobson\, C. M.\, Long-O'Donnell\, R.\, Rachubinski\, R. A. and\nAitchison
 \, J. D. (2008) Genome-wide analysis of signaling networks\nregulating fat
 ty acid-induced gene expression and organelle\nbiogenesis\, J Cell Biol\, 
 181: 281-292\nSmith\, J. J. and Aitchison\, J. D. (2009) Regulation of\npe
 roxisome dynamics\, Curr Opin Cell Biol.  Feb\;21(1):119-26.\nEpub 2009 Ja
 n 31.\nSaleem RA\, Rogers RS\, Ratushny AV\, Dilworth DJ\, Shannon PT\,\nS
 hteynberg D\, Wan Y\, Moritz RL\, Nesvizhskii AI\, Rachubinski RA\,\nAitch
 ison JD. (2010) Integrated phosphoproteomic analysis of a\nsignaling netwo
 rk governing nutrient response and peroxisome\ninduction\, Mol Cell Proteo
 mics. 2010 Apr 15. [Epub ahead of\nprint].\n
DTSTART:20100513T200000Z
DTEND:20100513T200000Z
LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr
 omenade Sir William Osler
SUMMARY:Biochemistry Seminar Dr. John Aitchison CANCELLED
URL:/channels/event/biochemistry-seminar-dr-john-aitch
 ison-cancelled-163322
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