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UID:20251226T130146EST-5840b3odF2@132.216.98.100
DTSTAMP:20251226T180146Z
DESCRIPTION:Dr François Major\, Institut de Recherche en Immunologie et en 
 Cancérologie and Département d'Informatique et de Recherche Opérationnelle
 \, Université de Montréal. We changed the classical rationale underlying R
 NA structure prediction by incorporating the contributions of the non-Wats
 on-Crick base pairs. To do so\, we defined a new first-order object for re
 presenting nucleotide relationships in structured RNAs\, which we call nuc
 leotide cyclic motif  (NCM) (1). In comparison to the classical stacks of 
 Watson-Crick base pairs\, the properties that make these particular buildi
 ng blocks appealing for structure determination are that: i) they embrace 
 indistinctly both canonical and non-canonical base pairs\; ii) they precis
 ely designate how any nucleotide in the sequence relates to others\; iii) 
 two adjacent blocks are merged through a common base pair\, allowing us to
  predict compatible chains of NCMs (2) and to assemble them in complete 3-
 D structures. We show here how the new approach i) reproduces accurately c
 onsensus/experimental 3-D structures from sequence data (cf. hairpins\, po
 lymorphic RNAs\, multi-branched RNAs)\, ii) incorporates multiple-sequence
  and low-resolution data\, and iii) improves the structural bases of RNAi 
 mechanisms\, such as precursor processing and siRNA targeting.\n
DTSTART:20071017T183000Z
DTEND:20071017T193000Z
LOCATION:Duff Medical Building\, CA\, QC\, Montreal\, H3A 2B4\, 3775 rue Un
 iversity
SUMMARY:MC-fold: A novel RNA folding approach based on nucleotide cyclic mo
 tifs and its application to RNAi
URL:/channels/event/mc-fold-novel-rna-folding-approach
 -based-nucleotide-cyclic-motifs-and-its-application-rnai-26832
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