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UID:20251010T022640EDT-6729xpKjcl@132.216.98.100
DTSTAMP:20251010T062640Z
DESCRIPTION:Dr. Deborah Baines\n\nProfessor of Molecular Physiology\, Infec
 tion and Immunity Research Institute\, St George's University of London\n
 \n \n\nTalk title: ‘’Interrogating the constituents of airway surface liqu
 id/sputum - friends and foes .’’\n\n \n\nThe lungs are lined with a thin f
 ilm of airway surface liquid (ASL) which contains a complex array of molec
 ules that play a key role in innate defence and mediate communication betw
 een the epithelium\, the immune cells\, and the external environment. The 
 ASL contains hundreds of proteins. Proteases and anti-proteases present in
  the ASL regulate the cleavage of these proteins and the generation of pep
 tides. Our investigation of the sputum peptidome from people with and with
 out Cystic Fibrosis (CF) has identified novel peptides with cellular\, ant
 imicrobial and antiviral bioactivity. In CF disease\, changes to the relat
 ive abundance of proteases\, anti-proteases and their activity alter the p
 roteomic and peptidomic profile of sputum and modify the ion transport pro
 perties of the airway epithelium in vitro.\n\n \n\nThis seminar will be gi
 ven online via Zoom. Details in attached poster.\n
DTSTART:20220118T160000Z
DTEND:20220118T170000Z
SUMMARY:CFTRc seminar - Dr. Deborah Baines
URL:/cftrc/channels/event/cftrc-seminar-dr-deborah-bai
 nes-336534
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